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  Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes

Engstler, M., Pfohl, T., Herminghaus, S., Boshart, M., Wiegertjes, G., Heddergott, N., et al. (2007). Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes. Cell, 131(3), 279-281. doi:10.1016/j.cell.2007.08.046.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-13F3-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-13F4-F
Genre: Journal Article

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 Creators:
Engstler, Markus, Author
Pfohl, Thomas1, Author              
Herminghaus, Stephan2, Author              
Boshart, Michael, Author
Wiegertjes, Geert, Author
Heddergott, Niko, Author
Peter Overath, Peter, Author
Affiliations:
1Group Dynamics of biological matter, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063313              
2Group Granular matter and irreversibility, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063306              

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 Abstract: The unicellular parasite Trypanosoma brucei rapidly removes host-derived immunoglobulin (Ig) from its cell surface, which is dominated by a single type of glycosylphosphatidylinositol-anchored variant surface glycoprotein (VSG). We have determined the mechanism of antibody clearance and found that Ig-VSG immune complexes are passively sorted to the posterior cell pole, where they are endocytosed. The backward movement of immune complexes requires forward cellular motility but is independent of endocytosis and of actin function. We suggest that the hydrodynamic flow acting on swimming trypanosomes causes directional movement of Ig-VSG immune complexes in the plane of the plasma membrane, that is, immunoglobulins attached to VSG function as molecular sails. Protein sorting by hydrodynamic forces helps to protect trypanosomes against complement-mediated immune destruction in culture and possibly in infected mammals but likewise may be of functional significance at the surface of other cell types such as epithelial cells lining blood vessels.

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Language(s): eng - English
 Dates: 2007-11-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 339884
DOI: 10.1016/j.cell.2007.08.046
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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 131 (3) Sequence Number: - Start / End Page: 279 - 281 Identifier: -