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  Dictyostelium discoideum chemotaxis: Threshold for directed motion

Song, L., Nadkarni, S. M., Bödeker, H. U., Beta, C., Bae, A., Franck, C., et al. (2006). Dictyostelium discoideum chemotaxis: Threshold for directed motion. European Journal of Cell Biology, 85(9-10), 981-989. doi:10.1016/j.ejcb.2006.01.012.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-14B1-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-14B2-0
Genre: Journal Article

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 Creators:
Song, Loling, Author
Nadkarni, Sharvari M., Author
Bödeker, Hendrik U., Author
Beta, Carsten1, Author              
Bae, Albert1, Author              
Franck, Carl, Author
Rappel, Wouter-Jan, Author
Loomis, William F., Author
Bodenschatz, Eberhard1, Author              
Affiliations:
1Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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Free keywords: Chemotaxis; Dictyostelium discoideum; Microfluidics
 Abstract: The chemotactic response of Dictyostelium discoideum cells to stationary, linear gradients of cyclic adenosine 3′,5′-monophosphate (cAMP) was studied using microfluidic devices. In shallow gradients of less than 10−3 nM/μm, the cells showed no directional response and exhibited a constant basal motility. In steeper gradients, cells moved up the gradient on average. The chemotactic speed and the motility increased with increasing steepness up to a plateau at around 10−1 nM/μm. In very steep gradients, above 10 nM/μm, the cells lost directionality and the motility returned to the sub-threshold level. In the regime of optimal response the difference in receptor occupancy at the front and back of the cell is estimated to be only about 100 molecules.

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 Dates: 2006-09-27
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 307459
DOI: 10.1016/j.ejcb.2006.01.012
 Degree: -

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Title: European Journal of Cell Biology
  Alternative Title : Eur. J. Cell Biol.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 85 (9-10) Sequence Number: - Start / End Page: 981 - 989 Identifier: -