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  Lateral prefrontal model-based signatures are reduced in healthy individuals with high trait impulsivity

Deserno, L., Wilbertz, T., Reiter, A., Horstmann, A., Neumann, J., Villringer, A., et al. (2015). Lateral prefrontal model-based signatures are reduced in healthy individuals with high trait impulsivity. Translational Psychiatry, 5: e659. doi:10.1038/tp.2015.139.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-31EC-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-78F7-0
Genre: Journal Article

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Deserno, Lorenz1, 2, 3, Author              
Wilbertz, T. 1, Author
Reiter, Andrea1, 4, Author              
Horstmann, Annette5, 6, Author              
Neumann, Jane5, 6, Author              
Villringer, Arno5, 6, 7, 8, Author              
Heinze, H. J.1, 3, 9, Author
Schlagenhauf, Florian1, 2, Author              
Affiliations:
1Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1753350              
2Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
4International Max Planck Research School on Neuroscience of Communication, Leipzig, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
8Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
9Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany, ou_persistent22              

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 Abstract: High impulsivity is an important risk factor for addiction with evidence from endophenotype studies. In addiction, behavioral control is shifted toward the habitual end. Habitual control can be described by retrospective updating of reward expectations in ‘model-free’ temporal-difference algorithms. Goal-directed control relies on the prospective consideration of actions and their outcomes, which can be captured by forward-planning ‘model-based’ algorithms. So far, no studies have examined behavioral and neural signatures of model-free and model-based control in healthy high-impulsive individuals. Fifty healthy participants were drawn from the upper and lower ends of 452 individuals, completing the Barratt Impulsiveness Scale. All participants performed a sequential decision-making task during functional magnetic resonance imaging (fMRI) and underwent structural MRI. Behavioral and fMRI data were analyzed by means of computational algorithms reflecting model-free and model-based control. Both groups did not differ regarding the balance of model-free and model-based control, but high-impulsive individuals showed a subtle but significant accentuation of model-free control alone. Right lateral prefrontal model-based signatures were reduced in high-impulsive individuals. Effects of smoking, drinking, general cognition or gray matter density did not account for the findings. Irrespectively of impulsivity, gray matter density in the left dorsolateral prefrontal cortex was positively associated with model-based control. The present study supports the idea that high levels of impulsivity are accompanied by behavioral and neural signatures in favor of model-free behavioral control. Behavioral results in healthy high-impulsive individuals were qualitatively different to findings in patients with the same task. The predictive relevance of these results remains an important target for future longitudinal studies.

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Language(s): eng - English
 Dates: 2015-07-302015-10-13
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/tp.2015.139
PMID: 26460483
PMC: PMC4930122
 Degree: -

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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 5 Sequence Number: e659 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: /journals/resource/2158-3188