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Ionotropic glutamate receptor channels; alternative splicing; mRNA editing; synaptic transmission
Abstract:
Ionotropic ligand-gated channels constitute a messenger RNA (alternative splicing, editing) and sublarge superfamily of channels that provide a molecular unit composition. In addition, interaction of receptor basis for synaptic transmission in central and peripheral subunits with postsynaptic density proteins plays a regnervous systems. These channels are subjects of ge- ulatory role and determines targets of channel insertion. nomic regulation at different levels. The final functional In this review, taking glutamate receptor channels as properties of each particular channel are determined by well-studied example, we illustrate how each of these type of gene family, posttranscriptional alterations of steps may determine receptor function in synapses
