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  Numerical Simulation and Nonlinear Control of a Continuous Yeast Bioreactor

Mubeen ur Rehman, S., Kiran, N., & Qamar, S. (2015). Numerical Simulation and Nonlinear Control of a Continuous Yeast Bioreactor. Journal of Chemical Engineering of Japan, 48(6), 472-480. doi:10.1252/jcej.14we194.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-4E26-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-4E27-6
Genre: Journal Article

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 Creators:
Mubeen ur Rehman, Shahzadi1, Author
Kiran, Nadia1, Author
Qamar, Shamsul1, 2, Author              
Affiliations:
1COMSATS Institute of Information Technology, Dep. of Mathematics, Islamabad, Pakistan, ou_persistent22              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, DE, ou_1738150              

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Free keywords: Saccharomyces Cerevisiae, Oscillatory Behavior, High Resolution Flux Limiting Finite Volume Schemes, Globally Linearizing Control
 Abstract: Here, the oscillatory behavior of Saccharomyces cerevisiae (baker’s yeast) was investigated during the operation of a continuous bioreactor as it is detrimental to the stability and productivity of such a system. An unstructured segregated model was employed to study this phenomenon. The mathematical model couples a biological cell population balance model (PBM), representing the dynamics of cell mass distribution, with the mass balance of the rate-limiting substrate. High resolution flux limiter finite volume schemes have been proposed for approximating model equations efficiently and accurately. Moreover, analytical solution of a simplified yeast cell PBM was derived and the accuracy of proposed numerical schemes was analyzed by comparing analytical and numerical solutions. Good agreements in results and error analysis proved the accuracy of the proposed numerical schemes. Finally, the Globally Linearizing Control (GLC) was used for obtaining the total cell mass per unit volume. The GLC damps oscillations in substrate concentration by controlling the total cell number per unit volume. The ability of this controller to stabilize the steady-state and periodic solutions was analyzed through numerical simulations.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1252/jcej.14we194
 Degree: -

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Title: Journal of Chemical Engineering of Japan
Source Genre: Journal
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Pages: - Volume / Issue: 48 (6) Sequence Number: - Start / End Page: 472 - 480 Identifier: -