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  Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy.

Ardenkjaer-Larsen, J. H., Boebinger, G. S., Comment, A., Duckett, S., Edison, A. S., Engelke, F., et al. (2015). Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy. Angewandte Chemie-International Edition, 54(32), 9162-9185. doi:10.1002/anie.201410653.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-3334-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-3402-9
Genre: Journal Article

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2180766.pdf (Publisher version), 9MB
 
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 Creators:
Ardenkjaer-Larsen, J. H., Author
Boebinger, G. S., Author
Comment, A., Author
Duckett, S., Author
Edison, A. S., Author
Engelke, F., Author
Griesinger, C.1, Author              
Griffin, R. G., Author
Hilty, C., Author
Maeda, H., Author
Parigi, G., Author
Prisner, T., Author
Ravera, E., Author
van Bentum, J., Author
Vega, S., Author
Webb, A., Author
Luchinat, C., Author
Schwalbe, H., Author
Frydman, L., Author
Affiliations:
1Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: NMR probeheads; NMR spectroscopy; nuclear hyperpolarization; sensitivity enhancement; ultrahigh magnetic fields
 Abstract: In the Spring of 2013, NMR spectroscopists convened at the Weizmann Institute in Israel to brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when applied in biomolecular settings. This multi-author interdisciplinary Review presents a state-of-the-art description of the primary approaches that were considered. Topics discussed included the future of ultrahigh-field NMR systems, emerging NMR detection technologies, new approaches to nuclear hyperpolarization, and progress in sample preparation. All of these are orthogonal efforts, whose gains could multiply and thereby enhance the sensitivity of solid- and liquid-state experiments. While substantial advances have been made in all these areas, numerous challenges remain in the quest of endowing NMR spectroscopy with the sensitivity that has characterized forms of spectroscopies based on electrical or optical measurements. These challenges, and the ways by which scientists and engineers are striving to solve them, are also addressed.

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Language(s): eng - English
 Dates: 2015-07-012015-08-03
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/anie.201410653
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Title: Angewandte Chemie-International Edition
Source Genre: Journal
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Pages: - Volume / Issue: 54 (32) Sequence Number: - Start / End Page: 9162 - 9185 Identifier: -