ausblenden:
Schlagwörter:
-
Zusammenfassung:
The ethanol solvolysis of 3-methoxy-14,17-etheno-16a-nitroestra-1,3,5(10)-trien-17b-yl acetate in the
presence of NaHCO3 was studied by means of real-time NMR experiments, LC–SPE–NMR, and LC–MS.
The pathway to form 3-methoxy-20-oxopyrrolidino-[40,50:14b,15b]-estra-1,3,5(10)-trien-17-one was
disclosed. The intermediacy of nitrile oxide and alkoxynitrone was postulated based on the analysis of
the reaction products. The proposed mechanism of cleaving the bridge in the nitro compound is legal
for the formation of N-acetoxylactams, nitriles, isoxazoles and isoxazolines.
