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  Physical exercise in overweight to obese individuals induces metabolic- and neurotrophic-related structural brain plasticity

Mueller, K., Möller, H. E., Horstmann, A., Busse, F. P., Lepsien, J., Blüher, M., et al. (2015). Physical exercise in overweight to obese individuals induces metabolic- and neurotrophic-related structural brain plasticity. Frontiers in Human Neuroscience, 9: 372. doi:10.3389/fnhum.2015.00372.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-3AE8-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-78F9-E
Genre: Journal Article

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 Creators:
Mueller, Karsten1, Author              
Möller, Harald E.1, Author              
Horstmann, Annette2, 3, Author              
Busse, Franziska P.2, Author              
Lepsien, Jöran1, Author              
Blüher, Matthias3, 4, Author
Stumvoll, Michael4, Author
Villringer, Arno2, 3, 5, Author              
Pleger, Burkhard2, 5, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Clinic for Endocrinology and Nephrology, University Hospital Leipzig, Germany, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: BDNF; Brain derived neurotrophic factor; Brain metabolism; Brain plasticity; Exercise; Magnetic resonance imaging; Obesity; Physical fitness
 Abstract: Previous cross-sectional studies on body-weight-related alterations in brain structure revealed profound changes in the gray matter (GM) and white matter (WM) that resemble findings obtained from individuals with advancing age. This suggests that obesity may lead to structural brain changes that are comparable with brain aging. Here, we asked whether weight-loss-dependent improved metabolic and neurotrophic functioning parallels the reversal of obesity-related alterations in brain structure. To this end we applied magnetic resonance imaging (MRI) together with voxel-based morphometry and diffusion-tensor imaging in overweight to obese individuals who participated in a fitness course with intensive physical training twice a week over a period of 3 months. After the fitness course, participants presented, with inter-individual heterogeneity, a reduced body mass index (BMI), reduced serum leptin concentrations, elevated high-density lipoprotein-cholesterol (HDL-C), and alterations of serum brain-derived neurotrophic factor (BDNF) concentrations suggesting changes of metabolic and neurotrophic function. Exercise-dependent changes in BMI and serum concentration of BDNF, leptin, and HDL-C were related to an increase in GM density in the left hippocampus, the insular cortex, and the left cerebellar lobule. We also observed exercise-dependent changes of diffusivity parameters in surrounding WM structures as well as in the corpus callosum. These findings suggest that weight-loss due to physical exercise in overweight to obese participants induces profound structural brain plasticity, not primarily of sensorimotor brain regions involved in physical exercise, but of regions previously reported to be structurally affected by an increased body weight and functionally implemented in gustation and cognitive processing.

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Language(s): eng - English
 Dates: 2015-03-052015-06-122015-07-01
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: PMID: 26190989
DOI: 10.3389/fnhum.2015.00372
PMC: PMC4486867
Other: eCollection 2015
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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 9 Sequence Number: 372 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: /journals/resource/1662-5161