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  Structure of the mammalian TSPO/PBR protein.

Jaremko, M., Jaremko, L., Jaipuria, G., Becker, S., & Zweckstetter, M. (2015). Structure of the mammalian TSPO/PBR protein. Biochemical Society Transactions, 43(4), 566-571. doi:10.1042/BST20150029.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-3A09-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1425-E
Genre: Journal Article

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 Creators:
Jaremko, M.1, Author              
Jaremko, L.1, Author              
Jaipuria, G., Author
Becker, S.1, Author              
Zweckstetter, M.2, Author              
Affiliations:
1Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578567              
2Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society, ou_578571              

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Free keywords: dynamics; nuclear magnetic resonance (NMR); peripheral benzodiazepine receptor; 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195); structure; TSPO
 Abstract: The 3D structure of the 18-kDa transmembrane (TM) protein TSPO (translocator protein)/PBR (peripheral benzodiazepine receptor), which contains a binding site for benzodiazepines, is important to better understand its function and regulation by endogenous and synthetic ligands. We have recently determined the structure of mammalian TSPO/PBR in complex with the diagnostic ligand PK11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; Jaremko et al. (2014) Science 343, 1363-1366], providing for the first time atomic-level insight into the conformation of this protein, which is up-regulated in various pathological conditions including Alzheimer's disease and Parkinson's disease. Here, we review the studies which have probed the structural properties of mammalian TSPO/PBR as well as the homologues bacterial tryptophan-rich sensory proteins (TspOs) over the years and provide detailed insight into the 3D structure of mouse TSPO (mTSPO)/PBR in complex with PK11195.

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Language(s): eng - English
 Dates: 2015-08
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1042/BST20150029
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Title: Biochemical Society Transactions
Source Genre: Journal
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Pages: - Volume / Issue: 43 (4) Sequence Number: - Start / End Page: 566 - 571 Identifier: -