English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis.

Chinen, I., Nakahama, T., Kimura, A., Nguyen, N. T., Takemori, H., Kumagai, A., et al. (2015). The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis. International Immunology, 27(8), 405-415. doi:10.1093/intimm/dxv015.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-3EEF-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-263D-3
Genre: Journal Article

Files

show Files
hide Files
:
2182669.pdf (Publisher version), 4MB
Name:
2182669.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2182669_Suppl.docx (Supplementary material), 115KB
Name:
2182669_Suppl.docx
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.wordprocessingml.document / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Chinen, I., Author
Nakahama, T., Author
Kimura, A., Author
Nguyen, N. T., Author
Takemori, H., Author
Kumagai, A., Author
Kayama, H., Author
Takeda, K., Author
Lee, S., Author
Hanieh, H., Author
Ripley, B., Author
Millrine, D., Author
Dubey, P. K., Author
Nyati, K. K., Author
Fujii-Kuriyama, Y., Author
Chowdhury, K.1, Author              
Kishimoto, T., Author
Affiliations:
1Facility of Microarray Analyses, MPI for biophysical chemistry, Max Planck Society, ou_578589              

Content

show
hide
Free keywords: aryl hydrocarbon receptor (Ahr); dextran sodium sulfate (DSS)-induced colitis; inflammatory bowel diseases (IBD); microRNA-212/132 (miR-212/132); type 1 regulatory T (Tr1) cells
 Abstract: Aryl hydrocarbon receptor (Ahr), a transcription factor, plays a critical role in autoimmune inflammation of the intestine. In addition, microRNAs (miRNAs), small non-coding oligonucleotides, mediate pathogenesis of inflammatory bowel diseases (IBD). However, the precise mechanism and interactions of these molecules in IBD pathogenesis have not yet been investigated. We analyzed the role of Ahr and Ahr-regulated miRNAs in colonic inflammation. Our results show that deficiency of Ahr in intestinal epithelial cells in mice exacerbated inflammation in dextran sodium sulfate-induced colitis. Deletion of Ahr in T cells attenuated colitis, which was manifested by suppressed T-h 17 cell infiltration into the lamina propria. Candidate miRNA analysis showed that induction of colitis elevated expression of the miR-212/132 cluster in the colon of wild-type mice, whereas in Ahr(-/-) mice, expression was clearly lower. Furthermore, miR-212/132(-/-) mice were highly resistant to colitis and had reduced levels of T-h 17 cells and elevated levels of IL-10-producing CD4(+) cells. In vitro analyses revealed that induction of type 1 regulatory T (Tr1) cells was significantly elevated in miR-212/132(-/-) T cells with increased c-Maf expression. Our findings emphasize the vital role of Ahr in intestinal homeostasis and suggest that inhibition of miR-212/132 represents a viable therapeutic strategy for treating colitis.

Details

show
hide
Language(s): eng - English
 Dates: 2015-04-102015-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/intimm/dxv015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: International Immunology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 27 (8) Sequence Number: - Start / End Page: 405 - 415 Identifier: -