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  Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation

Pengelly, A. R., Kalb, R., Finkl, K., & Müller, J. (2015). Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation. GENES & DEVELOPMENT, 29(14), 1487-1492. doi:10.1101/gad.265439.115.

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 Creators:
Pengelly, Ana Raquel1, Author           
Kalb, Reinhard1, Author           
Finkl, Katja1, Author           
Müller, Jürg1, Author           
Affiliations:
1Müller, Jürg / Chromatin Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565161              

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Free keywords: UBIQUITIN LIGASE COMPLEX; HISTONE H2A; POLYCOMB REPRESSION; CHROMATIN-STRUCTURE; X-INACTIVATION; IN-VIVO; RING1B; UBIQUITYLATION; PROTEINS; DOMAINPolycomb; PRC1; H2A and H2Av monoubiquitylation; transcriptional repression; Drosophila;
 Abstract: Histone H2A monoubiquitylation (H2Aub) is considered to be a key effector in transcriptional repression by Polycomb-repressive complex 1 (PRC1). We analyzed Drosophila with a point mutation in the PRC1 subunit Sce that abolishes its H2A ubiquitylase activity or with point mutations in the H2A and H2Av residues ubiquitylated by PRC1. H2Aub is essential for viability and required for efficient histone H3 Lys27 trimethylation by PRC2 early in embryogenesis. However, H2Aub-deficient animals fully maintain repression of PRC1 target genes and do not show phenotypes characteristic of Polycomb group mutants. PRC1 thus represses canonical target genes independently of H2Aub.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000358596300003
DOI: 10.1101/gad.265439.115
 Degree: -

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Title: GENES & DEVELOPMENT
Source Genre: Journal
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Publ. Info: 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA : COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Pages: - Volume / Issue: 29 (14) Sequence Number: - Start / End Page: 1487 - 1492 Identifier: ISSN: 0890-9369