English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  DNA-protein crosslink repair

Stingele, J., & Jentsch, S. (2015). DNA-protein crosslink repair. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 16(8), 455-460. doi:10.1038/nrm4015.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Stingele, Julian1, Author              
Jentsch, Stefan1, Author              
Affiliations:
1Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565156              

Content

show
hide
Free keywords: NUCLEOTIDE EXCISION-REPAIR; HOMOLOGOUS RECOMBINATION; TOPOISOMERASE-I; BIOLOGICAL CONSEQUENCES; RAD32(MRE11) NUCLEASE; HISTONE DEMETHYLATION; GENOMIC INSTABILITY; INDUCED MUTAGENESIS; DAMAGE RESPONSE; CELLS DEFICIENT
 Abstract: DNA-protein crosslinks (DPCs) are highly toxic DNA adducts, but whether dedicated DPC-repair mechanisms exist was until recently unknown. This has changed with discoveries made in yeast and Xenopus laevis that revealed a protease-based DNA-repair pathway specific for DPCs. Importantly, mutations in the gene encoding the putative human homologue of a yeast DPC protease cause a human premature ageing and cancer predisposition syndrome. Thus, DPC repair is a previously overlooked genome-maintenance mechanism that may be essential for tumour suppression.

Details

show
hide
Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000358530400005
DOI: 10.1038/nrm4015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NATURE REVIEWS MOLECULAR CELL BIOLOGY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 16 (8) Sequence Number: - Start / End Page: 455 - 460 Identifier: ISSN: 1471-0072