English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Multicontrast MRI quantification of focal inflammation and degeneration in multiple sclerosis.

Bonnier, G., Roche, A., Romascano, D., Simioni, S., Meskaldji, D. E., Rotzinger, D., et al. (2015). Multicontrast MRI quantification of focal inflammation and degeneration in multiple sclerosis. BioMed Research International, 2015: 569123. doi:10.1155/2015/569123.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-418D-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0857-C
Genre: Journal Article

Files

show Files
hide Files
:
2181831.pdf (Publisher version), 3MB
Name:
2181831.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2181831_Suppl.pdf (Supplementary material), 66KB
Name:
2181831_Suppl.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Bonnier, G., Author
Roche, A., Author
Romascano, D., Author
Simioni, S., Author
Meskaldji, D. E., Author
Rotzinger, D., Author
Lin, Y. C., Author
Menegaz, G., Author
Schluep, M., Author
Du Pasquier, R., Author
Sumpf, T.1, Author              
Frahm, J.1, Author              
Thiran, J. P., Author
Krueger, G., Author
Granziera, C., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

Content

show
hide
Free keywords: -
 Abstract: Introduction. Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability. Methods. 36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2* relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of inflammation/neurodegeneration. A generalized linear model assessed the contribution of lesion groups to clinical performances. Results. Four lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent inflammation, (3) concomitant inflammation and microdegeneration, and (4) prevalent tissue loss. Groups 1, 3, 4 correlated with general disability (Adj-R-2 = 0.6; P = 0.0005), executive function (Adj-R-2 = 0.5; P - 0.004), verbal memory (Adj-R-2 - 0.4; P - 0.02), and attention (Adj-R-2 - 0.5; P - 0.002). Conclusion. Multicontrast MRI provides a new approach to infer in vivo histopathology of plaques. Our results support evidence that neurodegeneration is the major determinant of patients' disability and cognitive dysfunction.

Details

show
hide
Language(s): eng - English
 Dates: 2015
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1155/2015/569123
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: BioMed Research International
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 9 Volume / Issue: 2015 Sequence Number: 569123 Start / End Page: - Identifier: -