English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The status of high-valent metal oxo complexes in the P450 cytochromes

Makris, T. M., von König, K., Schlichting, I., & Sligar, S. G. (2006). The status of high-valent metal oxo complexes in the P450 cytochromes. Journal of Inorganic Biochemistry, 100(4), 507-518. doi:10.1016/j.jinorgbio.2006.01.025.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : The status of high-valent metal oxo complexes in the P450 cytochromes

Files

show Files
hide Files
:
JInorgBiochem_100_2006_507.pdf (Any fulltext), 453KB
 
File Permalink:
-
Name:
JInorgBiochem_100_2006_507.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Makris, Thomas M., Author
von König, Konstanze1, Author              
Schlichting, Ilme1, Author              
Sligar, Stephen G., Author
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

Content

show
hide
Free keywords: P450; Compound I; Ferryl; Meta-Oxo; X-ray
 Abstract: The oxidative prowess of the P450 cytochromes in physiological reactions is attributed to the production of a high-valent iron-oxo complex, or Compound I intermediate, in the reaction cycle. Despite many years of study, however, the full electronic description of this fleeting intermediate still remains an active area of study. In this manuscript, the current status of the isolation and characterization of the P450 oxo-Fe(IV) is examined and compared to analogous states in related heme enzymes. In addition, the utilization of cofactor exchange to stabilize high-valent oxo-states in the P450 is addressed. Structural and spectroscopic studies on manganese reconstituted P450, and its corresponding oxo-complex, are presented.

Details

show
hide
Language(s): eng - English
 Dates: 2006-01-172005-12-192006-01-172006-02-282006-04-01
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Inorganic Biochemistry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 100 (4) Sequence Number: - Start / End Page: 507 - 518 Identifier: ISSN: 0162-0134
CoNE: https://pure.mpg.de/cone/journals/resource/954925478535