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  Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications

Ferreira dos Santos, C., Gomes, P. S., Almeida, M. M., Willinger, M. G., Franke, R.-P., Fernandes, M. H., et al. (2015). Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications. RSC Advances, 5(85), 69184-69195. doi:10.1039/c5ra11978b.

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 Creators:
Ferreira dos Santos, Catarina1, 2, Author
Gomes, Pedro Sousa3, 4, Author
Almeida, Maria Margarida5, Author
Willinger, Marc Georg6, Author           
Franke, Ralf-Peter7, Author
Fernandes, Maria Helena3, 4, Author
Costa, Maria Elisabete5, Author
Affiliations:
1Department of Mechanical Engineering, Escola Superior de Tecnologia de Setúbal, Instituto Politécnico de Setúbal, Setúbal, Portugal , ou_persistent22              
2ICEMS, Instituto Superior Técnico, Technical University of Lisbon, Av. Rovisco Pais, Lisboa 1049 001, Portugal , ou_persistent22              
3Laboratory for Bone Metabolism and Regeneration, Faculdade de Medicina Dentária, Universidade do Porto, Porto, Portugal , ou_persistent22              
4MedInUP – Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal , ou_persistent22              
5Department of Materials and Ceramics Engineering, CICECO, Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal , ou_persistent22              
6Inorganic Chemistry, Fritz Haber Institute, Max Planck Society, ou_24023              
7Central Institute for Biomedical Technology, Biomaterials Division, University of Ulm, Ulm, Germany , ou_persistent22              

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 Abstract: A novel synthetic approach for coupling metallic gold nanoparticles (AuNPs) to the facets of hydroxyapatite crystalline nanoparticles (HapNPs) without an additional reducing agent was developed. Hexagonal prism-shaped hydroxyapatite nanoparticles (HapNPs) were first precipitated by a hydrothermal route assisted by citric acid, which left behind carboxylate species adsorbed on the HapNP facets. HapNP were then used as templates for gold precipitation. Upon exposure to gold ions, the carboxylate species on the HapNP prismatic facets were able to trigger the nucleation of metallic gold by reducing the gold ions in situ. The used conditions did not allow for the extensive growth of gold nuclei and hence gold dots with diameters not larger than 2.5 nm were formed on the HapNP facets. The obtained (Hap–AuNP) heteronanostructures combine Hap nanoprisms, a highly biocompatible material easily recognised by the human body, with metallic nanosized gold that imparts a plasmon resonance (SPR) effect to the synthesized nanostructures, which is of great potential for further exploration within the contexts of thermotherapy and imaging strategies. Human mesenchymal stem cells were exposed to a range of Hap–AuNP concentrations, but no cytotoxic effects from the heteronanostructures were observed. Furthermore, Hap–AuNP greatly enhanced Runx2 and ALP expressions. In addition, these results predict that the synthesized Hap–AuNP particles could hold potential interest for medical applications requiring nontoxic materials capable of bone-defect repair and furthermore exhibiting SPR properties, which can be potentially advantageous for therapeutic and diagnostic purposes.

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Language(s): eng - English
 Dates: 2015-06-222015-07-232015-07-23
 Publication Status: Published online
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/c5ra11978b
 Degree: -

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Title: RSC Advances
  Abbreviation : RSC Adv.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 5 (85) Sequence Number: - Start / End Page: 69184 - 69195 Identifier: ISSN: 2046-2069
CoNE: https://pure.mpg.de/cone/journals/resource/2046-2069