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  Continuous and convergent access to vicinyl amino alcohols

Nobuta, T., Xiao, G., Ghislieri, D., Gilmore, K., & Seeberger, P. H. (2015). Continuous and convergent access to vicinyl amino alcohols. Chemical Communications, 51, 15133-15136. doi:10.1039/C5CC06093A.

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 Creators:
Nobuta, Tomoya1, Author              
Xiao, Guozhi2, Author              
Ghislieri, Diego2, Author              
Gilmore, Kerry1, Author              
Seeberger, Peter H.3, Author              
Affiliations:
1Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863304              
2Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              
3Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: Open Access
 Abstract: Five active pharmaceutical ingredients (APIs) containing the vicinyl amino alcohol moiety were synthesized using a convergent chemical assembly system. The continuous system is composed of four flow reaction modules: biphasic oxidation, Corey–Chaykovsky epoxidation, phenol alkylation, and epoxide aminolysis. Judicious choice of reagents and module order allowed for two classes of β-amino alcohols, aryl and aryloxy, to be synthesized in good (27–69%) overall yields.

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 Dates: 2015-08-242015
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/C5CC06093A
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 51 Sequence Number: - Start / End Page: 15133 - 15136 Identifier: ISSN: 1359-7345