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  Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis

Simons, M., & Trajkovic, K. (2006). Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis. Journal of Cell Science, 119(21), 4381-4389. doi:10.1242/jcs.03242.

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 Creators:
Simons, Mikael1, Author           
Trajkovic, Katarina1, 2, Author           
Affiliations:
1Cellular neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173650              
2Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              

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Free keywords: Neurons; Oligodendrocytes; Myelin; Central nervous system; Axon initial segments; Raft associated protein; Cell adhesion molecule; Beta IV spectrin; Rat optic nerve; Growth factor; Proteolipid protein; Schwann cells; Action potentials
 Abstract: During the development of the central nervous system the reciprocal communication between neurons and oligodendrocytes is essential for the generation of myelin, a multilamellar insulating membrane that ensheathes the axons. Neuron-derived signalling molecules regulate the proliferation, differentiation and survival of oligodendrocytes. Furthermore, neurons control the onset and timing of myelin membrane growth. In turn, signals from oligodendrocytes to neurons direct the assembly of specific subdomains in neurons at the node of Ranvier. Recent work has begun to shed light on the molecules and signaling systems used to coordinate the interaction of neurons and oligodendrocytes. For example, the neuronal signals seem to control the membrane trafficking machinery in oligodendrocytes that leads to myelination. These interconnections at multiple levels show how neurons and glia cooperate to build a complex network during development.

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 Dates: 2006-11
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 711979
ISI: 000241893200003
ISI: 000241893200003
DOI: 10.1242/jcs.03242
 Degree: -

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Title: Journal of Cell Science
Source Genre: Journal
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Pages: - Volume / Issue: 119 (21) Sequence Number: - Start / End Page: 4381 - 4389 Identifier: ISSN: 0021-9533