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  A novel mode of tangential migration of cortical projection neurons

Britanova, O. V., Alifragis, P., Junek, S., Jones, K., Gruss, P., & Tarabykin, V. (2006). A novel mode of tangential migration of cortical projection neurons. Developmental Biology, 298(1), 299-311.

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 Creators:
Britanova, Olga V.1, Author              
Alifragis, Pavlos1, Author              
Junek, Stephan2, Author              
Jones, Kevin, Author
Gruss, Peter, Author
Tarabykin, Victor1, Author              
Affiliations:
1Molecular biology of neuronal signals, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173656              
2Cortical development, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173652              

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Free keywords: Cerebral cortex; Reelin; Transcription factor; Migration; Cre; Transgenic; Cell fate; Subiculum developing cerebral-cortex; Radial migration; Subventricular zone; Fate determination; Gabaergic neurons; Expression; Reeler; Proteins; Lineage; CNS
 Abstract: Projection neurons of the developing cerebral cortex are generated in the cerebral ventricular zone and subsequently move to the developing cortical plate via radial migration. Conversely, most inhibitory interneurons originate in the ganglionic eminences and enter the developing cortical plate by tangential migration. Using immunohistochemical analysis together with tracer labeling experiments in organotypic brain slices, we show that a portion of cortical projection neurons migrates tangentially over long distances. Lineage analysis revealed that these neurons are derived from Emx1+ cortical progenitors and express the transcription factor Satb2 but do not express GABA or Olig1. In vitro and in vivo analysis of reeler mutant brains demonstrated that although reeler mutation does not influence tangential migration of interneurons, it affects the tangential migration of cortical projection neurons. (c) 2006 Elsevier Inc. All rights reserved.

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Language(s): eng - English
 Dates: 2006-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 292145
ISI: 000241071100026
ISI: 000241071100026
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Title: Developmental Biology
  Alternative Title : Dev. Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 298 (1) Sequence Number: - Start / End Page: 299 - 311 Identifier: ISSN: 0012-1606