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  Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS

Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K.-A., et al. (2006). Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS. The Journal of Neuroscience, 26(40), 10110-10119. doi:10.1523/JNEUROSCI.2158-06.2006.

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 Creators:
Thurnherr, Tina, Author
Benninger, Yves, Author
Wu, Xunwei, Author
Chrostek, Anna, Author
Krause, Sven M., Author
Nave, Klaus-Armin1, Author           
Franklin, Robin J. M., Author
Brakebusch, Cord, Author
Suter, Ueli, Author
Relvas, Joao B., Author
Affiliations:
1Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              

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Free keywords: cdc42; rac1; Rho GTPase; myelin; CNS; oligodendrocyte CELL-CELL ADHESION; RHO-GTPASES; SPINAL-CORD; GROWTH-FACTOR; OLIGODENDROCYTES; MIGRATION; DIFFERENTIATION; BETA-1-INTEGRIN; ORGANIZATION; CYTOSKELETON
 Abstract: The formation of myelin sheaths in the CNS is the result of a complex series of events involving oligodendrocyte progenitor cell (OPC) proliferation, directed migration, and the morphological changes associated with axon ensheathment and myelination. To examine the role of Rho GTPases in oligodendrocyte biology, we have used a conditional tissue-specific gene-targeting approach. Ablation of Cdc42 in cells of the oligodendrocyte lineage did not affect OPC proliferation, directed migration, or in vitro differentiation, but it led to the formation of a unique and stage-specific myelination phenotype. This was characterized by the extraordinary enlargement of the inner tongue of the oligodendrocyte process and concomitant formation of a myelin outfolding as a result of abnormal accumulation of cytoplasm in this region. Ablation of Rac1 also resulted in the abnormal accumulation of cytoplasm in the inner tongue of the oligodendrocyte process, and we provide genetic evidence that rac1 synergizes with cdc42 in a gene dosage-dependent way to regulate myelination.

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Language(s): eng - English
 Dates: 2006-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.2158-06.2006
 Degree: -

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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 26 (40) Sequence Number: - Start / End Page: 10110 - 10119 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1