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  Neuroligins determine synapse maturation and function

Varoqueaux, F., Aramuni, G., Rawson, R. L., Mohrmann, R., Missler, M., Gottmann, K., et al. (2006). Neuroligins determine synapse maturation and function. Neuron, 51(6), 741-754. doi:10.1016/j.neuron.2006.09.003.

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Varoqueaux, Frédérique1, Author           
Aramuni, Gayane, Author
Rawson, Randi L.1, Author           
Mohrmann, Ralf, Author
Missler, Markus, Author
Gottmann, Kurt1, Author           
Zhang, Weiqi, Author
Südhof, Thomas C., Author
Brose, Nils1, Author           
Affiliations:
1Molecular neurobiology, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173659              

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Free keywords: ALPHA-NEUREXINS; EXCITATORY SYNAPSES; INHIBITORY SYNAPSES; BETA-NEUREXINS; CA2+ CHANNELS; AUTISM; PSD-95; BINDING; PROTEIN; RECEPTORS
 Abstract: Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to respiratory failure. This respiratory failure is a consequence of reduced GABAergic/glycinergic and glutamatergic synaptic transmission and network activity in brainstem centers that control respiration. However, the density of synaptic contacts is not altered in neuroligin-deficient brains and cultured neurons. Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts.

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Language(s): eng - English
 Dates: 2006-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 292156
ISI: 000240997900013
ISI: 000240997900013
DOI: 10.1016/j.neuron.2006.09.003
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Title: Neuron
  Alternative Title : Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 51 (6) Sequence Number: - Start / End Page: 741 - 754 Identifier: ISSN: 0896-6273