非表示:
キーワード:
integrins; oligodendrocytes; survival; myelin; remyelination; CNS MULTIPLE-SCLEROSIS; EXTRACELLULAR-MATRIX; ADHESION MOLECULE; CELL-ADHESION; IN-VITRO; INTEGRINS; EXPRESSION; DIFFERENTIATION; PROLIFERATION; DISRUPTION
要旨:
Previous reports, including transplantation experiments using dominant-negative inhibition of beta 1-integrin signaling in oligodendrocyte progenitor cells, suggested that beta 1-integrin signaling is required for myelination. Here, we test this hypothesis using conditional ablation of the beta 1-integrin gene in oligodendroglial cells during the development of the CNS. This approach allowed us to study oligodendroglial beta 1-integrin signaling in the physiological environment of the CNS, circumventing the potential drawbacks of a dominant-negative approach. We found that beta 1-integrin signaling has a much more limited role than previously expected. Although it was involved in stage-specific oligodendrocyte cell survival, beta 1-integrin signaling was not required for axon ensheathment and myelination per se. We also found that, in the spinal cord, remyelination occurred normally in the absence of beta 1-integrin. We conclude that, although beta 1-integrin may still contribute to other aspects of oligodendrocyte biology, it is not essential for myelination and remyelination in the CNS.
