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  Potassium channels as tumour markers

Stühmer, W., Alves, F., Hartung, F., Zientkowska, M., & Pardo, L. A. (2006). Potassium channels as tumour markers. FEBS Letters, 580(12), 2850-2852.

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 Creators:
Stühmer, Walter1, Author              
Alves, Frauke2, Author              
Hartung, Franziska1, Author              
Zientkowska, Marta, Author
Pardo, Luis A.1, Author              
Affiliations:
1Molecular biology of neuronal signals, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173656              
2Translational molecular imaging, Molecular biology of neuronal signals, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173658              

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Free keywords: EAG; cancer; ion channels; oncogene; near-infrared imaging HUMAN PROSTATE-CANCER; EAG K+ CHANNELS; A-GO-GO; MELANOMA-CELLS; PLASMA-MEMBRANE; BREAST-CANCER; ION CHANNELS; EXPRESSION; PROLIFERATION; ETHER
 Abstract: An increasing number of ion channels are being found to be causally involved in diseases, giving rise to the new field of "channelopathies". Cancer is no exception, and several ion channels have been linked to tumour progression. Among them is the potassium channel EAG (Ether-a-go-go). Over 75% of tumours have been tested positive using a monoclonal antibody specific for EAG, while inhibition of this channel decreased the proliferation of EAG expressing cells. The inhibition of EAG is accomplished using RNA interference, functional anti-EAG1 antibodies, or (unspecific) EAG channel blockers. Fluorescently labelled recombinant Fab fragments recognizing EAG allow the distribution of EAG to be visualized in an in vivo mouse tumour model. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2006-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 292189
ISI: 000238167200009
ISI: 000238167200009
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Title: FEBS Letters
  Alternative Title : FEBS Lett.
Source Genre: Journal
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Pages: - Volume / Issue: 580 (12) Sequence Number: - Start / End Page: 2850 - 2852 Identifier: ISSN: 0014-5793