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  Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin

Sirén, A.-L., Radyushkin, K., Boretius, S., Kämmer, D., Riechers, C.-C., Natt, O., et al. (2006). Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin. Brain, 129, 480-489. doi:10.1093/brain/awh703.

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 Creators:
Sirén, Anna-Leena1, Author              
Radyushkin, Konstantin1, Author              
Boretius, Susann, Author
Kämmer, Daniel1, Author              
Riechers, Claas-Christian1, Author              
Natt, Oliver, Author
Sargin, Derya1, Author              
Watanabe, Takashi, Author
Sperling, Swetlana1, Author              
Michaelis, Thomas, Author
Price, Jack, Author
Meyer, Barbara, Author
Frahm, Jens, Author
Ehrenreich, Hannelore1, Author              
Affiliations:
1Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173651              

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Free keywords: EPO; MRI; neuroprotection; neurodegeneration; neurotrauma; schizophrenia DENTATE GYRUS; IN-VIVO; HIPPOCAMPAL NEUROGENESIS; CEREBRAL-ISCHEMIA; HEAD-INJURY; RAT; ADULT; SCHIZOPHRENIA; MICE; DYSFUNCTION
 Abstract: In humans, neurotrauma is suspected to cause brain atrophy and accelerate slowly progressive neurodegenerative disorders, such as Alzheimer's disease or schizophrenia. However, a direct link between brain injury and subsequent delayed global neurodegeneration has remained elusive. Here we show that juvenile (4-week-old) mice that are given a discrete unilateral lesion of the parietal cortex, develop to adulthood without obvious clinical symptoms. However, when monitored 3 and 9 months after lesioning, using high-resolution three-dimensional MRI and behavioural testing, the same mice display global neurodegenerative changes. Surprisingly, erythropoietin, a haematopoietic growth factor with potent neuroprotective activity, prevents behavioural abnormalities, cognitive dysfunction and brain atrophy when given for 2 weeks after acute brain injury. This demonstrates that a localized brain lesion is a primary cause of delayed global neurodegeneration that can be efficiently counteracted by neuroprotection.

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Language(s): eng - English
 Dates: 2006-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 292201
ISI: 000234965500019
ISI: 000234965500019
DOI: 10.1093/brain/awh703
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Title: Brain
  Alternative Title : Brain
Source Genre: Journal
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Pages: - Volume / Issue: 129 Sequence Number: - Start / End Page: 480 - 489 Identifier: ISSN: 0006-8950