English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., et al. (2004). Axonal Neuregulin-1 Regulates Myelin Sheath Thickness. Science, 304(5671), 700-703. doi:10.1126/science.1095862.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-3010-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-1F4B-E
Genre: Journal Article

Files

show Files
hide Files
:
Michailov_04.pdf (Publisher version), 425KB
 
File Permalink:
-
Name:
Michailov_04.pdf
Description:
-
OA-Status:
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
eDoc_access: MPG
License:
-

Locators

show

Creators

show
hide
 Creators:
Michailov, Galin V.1, Author           
Sereda, Michael W.2, Author           
Brinkmann, Bastian G.1, Author           
Fischer, Tobias M.1, Author           
Haug, Bernhard, Author
Birchmeier, Carmen, Author
Role, Lorna, Author
Lai, Cary, Author
Schwab, Markus H.1, Author           
Nave, Klaus-Armin1, Author           
Affiliations:
1Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              
2Molecular and translational neurology, Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173667              

Content

show
hide
Free keywords: -
 Abstract: In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells. Reduced Nrg1 expression causes hypomyelination and reduced nerve conduction velocity. Neuronal overexpression of Nrg1 induces hypermyelination and demonstrates that Nrg1 type III is the responsible isoform. We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size.

Details

show
hide
Language(s): eng - English
 Dates: 2004-04-30
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.1095862
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Science
  Abbreviation : Science
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 304 (5671) Sequence Number: - Start / End Page: 700 - 703 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1