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  Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: Interactions between Erk-1/2 and Elk-1

Sananbenesi, F., Fischer, A., Schrick, C., Spiess, J., & Radulovic, J. (2002). Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: Interactions between Erk-1/2 and Elk-1. Molecular and Cellular Neuroscience, 21(3), 463-476.

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 Creators:
Sananbenesi, Farahnaz1, Author           
Fischer, André1, Author           
Schrick, Christina1, Author           
Spiess, Joachim1, Author           
Radulovic, Jelena1, Author           
Affiliations:
1Molecular neuroendocrinology, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173662              

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 Abstract: The phosphorylation of proteins involved in the MAP kinase signal transduction pathway was investigated during associative learning of C57BL/6J mice. Context-dependent fear conditioning, consisting of a single exposure of mice to a context followed by foot shock, was employed as a learning paradigm. Control groups consisted of mice exposed to context only or an immediate shock in the context. Coincident up-regulation of phosphorylated Erk-1/2 and Elk-1 was observed in the CA3 hippocampal subfield and dentate gyrus 30 min after fear conditioning but not after the control paradigms. Phosphorylated Erk-1/2 and Elk-1 were associated and predominantly colocalized in the mossy fibers. In vitro kinase assays showed that hippocampal Erk-1/2 phosphorylates Elk-1. Notably, Elk-1 in turn enhances the phosphorylation of Erk-1/2 and its downstream target p90Rsk-1. Increased phosphorylation and nuclear translocation of p90Rsk-1 was also demonstrated in the CA3 hippocampal area in vivo during contextual fear conditioning. The observed interactions between hippocampal Elk-1 and Erk-1/2 proteins may affect the consolidation of contextual memories through activation of the downstream nuclear targets of Erk-1/2, such as p90Rsk-1, without requiring nuclear translocation of Elk-1 and Erk-1/2.

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Language(s): eng - English
 Dates: 2002-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 19788
ISI: 000180054800008
 Degree: -

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Title: Molecular and Cellular Neuroscience
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 21 (3) Sequence Number: - Start / End Page: 463 - 476 Identifier: ISSN: 1044-7431
CoNE: https://pure.mpg.de/cone/journals/resource/954922650153