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  Notch1 control of oligodendrocyte differentiation in the spinal cord

Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S. S., et al. (2002). Notch1 control of oligodendrocyte differentiation in the spinal cord. The Journal of Cell Biology: JCB, 158(4), 709-718.

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Genoud, S., Author
Lappe-Siefke, Corinna1, Author           
Goebbels, Sandra2, Author           
Radtke, F., Author
Aguet, M., Author
Scherer, S. S., Author
Suter, U., Author
Nave, Klaus-Armin1, Author           
Mantei, N., Author
Affiliations:
1Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              
2Developmental neurobiology, Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173665              

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Free keywords: ectopic expression; brain; Cre-lox P; newborn; apoptosis
 Abstract: We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared normal in the spinal cord. However, at embryonic day 17.5, premature OL differentiation was observed and ectopic immature OLs were present in the gray matter. At birth, OL apoptosis was strongly increased in Notch I mutant animals. Premature OL differentiation was also observed in the cerebrum, indicating that Notch1 is required for the correct spatial and temporal regulation of OL differentiation in various regions of the central nervous system. These findings establish a widespread function of Notch1 in the late steps of mammalian OPC development in vivo.

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Language(s): eng - English
 Dates: 2002-08-19
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 18215
ISI: 000177649900011
 Degree: -

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Title: The Journal of Cell Biology : JCB
  Other : J. Cell Biol.
Source Genre: Journal
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Publ. Info: New York, NY : Rockefeller Institute Press
Pages: - Volume / Issue: 158 (4) Sequence Number: - Start / End Page: 709 - 718 Identifier: ISSN: 0021-9525
CoNE: https://pure.mpg.de/cone/journals/resource/991042742946024