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  Cyclin-dependent kinase 5 is required for associative learning

Fischer, A., Sananbenesi, F., Schrick, C., Spiess, J., & Radulovic, J. (2002). Cyclin-dependent kinase 5 is required for associative learning. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 22(9), 3700-3707.

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 Creators:
Fischer, Andre1, Author           
Sananbenesi, Farahnaz1, Author           
Schrick, Christina1, Author           
Spiess, Joachim1, Author           
Radulovic, Jelena1, Author           
Affiliations:
1Molecular neuroendocrinology, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173662              

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Free keywords: cyclin-dependent kinase 5; stress; fear conditioning; septum; hippocampus; cholinergic; mice
 Abstract: Transient stressful experiences may persistently facilitate associative and nonassociative learning, possibly through alterations of gene expression. Here we identify, by subtractive hybridization, differential expression of the Cdk5 gene in response to stress. The Cdk5 protein is selectively induced in the fibers of septohippocampal cholinergic neurons but not in other regions of prominent Cdk5 production. This upregulation is accompanied by increased Cdk5 kinase activity, which is blocked completely by the Cdk5 inhibitor butyrolactone I. Microinjection of butyrolactone I into the lateral septum and hippocampus prevents the acquisition of conditioned context-dependent fear as well as its stress-induced facilitation. By demonstrating that a transient increase of Cdk5 activity within the septohippocampal system is required for associative learning, an important novel role of Cdk5 has been identified.

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Language(s): eng - English
 Dates: 2002-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 18999
ISI: 000175296200047
 Degree: -

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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
 Creator(s):
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 22 (9) Sequence Number: - Start / End Page: 3700 - 3707 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1