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  Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network

Partridge, L., Alic, N., Bjedov, I., & Piper, M. D. (2011). Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol, 46(5), 376-81. doi:S0531-5565(10)00292-5 [pii] 10.1016/j.exger.2010.09.003.

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 Creators:
Partridge, L.1, Author
Alic, N.1, Author
Bjedov, I.1, Author
Piper, M. D.1, Author
Affiliations:
1Max Planck Society, ou_persistent13              

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Free keywords: Aging/*physiology Animals Drosophila Proteins/*physiology Drosophila melanogaster/*physiology Insulin/*physiology Models, Animal Protein Kinases/*physiology Signal Transduction/physiology Somatomedins/*physiology
 Abstract: A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways involved have often proved to sense nutrients and to match costly activities of organisms, such as growth, metabolism and reproduction, to nutrient status. For instance, the insulin/insulin-like growth factor and Target of Rapamycin signalling network has proved to play a function in ageing, from yeast to mammals, seemingly including humans. In the fruit fly Drosophila, altered activity of several components of this network can increase lifespan and improve locomotor and cardiac function during ageing. The fly brain, fat body (equivalent of mammalian liver and white adipose tissue) and the germ line are important in determination of lifespan, with considerable communication between different tissues. Cellular detoxification pathways, increased autophagy and altered protein synthesis have all been implicated in increased lifespan from reduced IIS/TOR activity, with the role of defence against oxidative stress unresolved. Reduced IIS/TOR signalling can alter or block the response of lifespan to dietary restriction. Reduced IIS can act acutely to lower death rate, implying that it may ameliorate the effects of ageing-related damage, rather than preventing it.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 20849947
DOI: S0531-5565(10)00292-5 [pii] 10.1016/j.exger.2010.09.003
ISSN: 1873-6815 (Electronic) 0531-5565 (Linking)
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Title: Exp Gerontol
Source Genre: Journal
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Pages: - Volume / Issue: 46 (5) Sequence Number: - Start / End Page: 376 - 81 Identifier: -