English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals

Wredenberg, A., Lagouge, M., Bratic, A., Metodiev, M. D., Spahr, H., Mourier, A., et al. (2013). MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PLoS Genet, 9(1), e1003178. doi:10.1371/journal.pgen.1003178.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5A03-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5A04-2
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Wredenberg, A.1, Author
Lagouge, M.1, Author
Bratic, A.1, Author
Metodiev, M. D.1, Author
Spahr, H.1, Author
Mourier, A.1, Author
Freyer, C.1, Author
Ruzzenente, B.1, Author
Tain, L.1, Author
Gronke, S.1, Author
Baggio, F.1, Author
Kukat, C.1, Author
Kremmer, E.1, Author
Wibom, R.1, Author
Polosa, P. L.1, Author
Habermann, B.1, Author
Partridge, L.1, Author
Park, C. B.1, Author
Larsson, N. G.1, Author
Affiliations:
1Max Planck Society, ou_persistent13              

Content

show
hide
Free keywords: Animals DNA, Mitochondrial/genetics *Drosophila Proteins/genetics Drosophila melanogaster/*genetics Gene Expression Regulation Invertebrates/genetics/metabolism Mice *Mitochondria/genetics/metabolism *Mitochondrial Proteins/genetics Oxidative Phosphorylation *Ribosomes/genetics/metabolism Transcription, Genetic
 Abstract: Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial transcription termination factor 3 (MTERF3) is a key regulator that represses mtDNA transcription in the mouse, but its molecular mode of action has remained elusive. Based on the hypothesis that key regulatory mechanisms for mtDNA expression are conserved in metazoans, we analyzed Mterf3 knockout and knockdown flies. We demonstrate here that decreased expression of MTERF3 not only leads to activation of mtDNA transcription, but also impairs assembly of the large mitochondrial ribosomal subunit. This novel function of MTERF3 in mitochondrial ribosomal biogenesis is conserved in the mouse, thus we identify a novel and unexpected role for MTERF3 in coordinating the crosstalk between transcription and translation for the regulation of mammalian mtDNA gene expression.

Details

show
hide
Language(s):
 Dates: 2013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: Other: 23300484
DOI: 10.1371/journal.pgen.1003178
ISSN: 1553-7404 (Electronic) 1553-7390 (Linking)
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLoS Genet
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 9 (1) Sequence Number: - Start / End Page: e1003178 Identifier: -