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  MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals

Wredenberg, A., Lagouge, M., Bratic, A., Metodiev, M. D., Spahr, H., Mourier, A., et al. (2013). MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PLoS Genet, 9(1), e1003178. doi:10.1371/journal.pgen.1003178.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5A03-4 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5A04-2
Genre: Zeitschriftenartikel

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http://www.ncbi.nlm.nih.gov/pubmed/23300484 (beliebiger Volltext)
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 Urheber:
Wredenberg, A.1, Autor
Lagouge, M.1, Autor
Bratic, A.1, Autor
Metodiev, M. D.1, Autor
Spahr, H.1, Autor
Mourier, A.1, Autor
Freyer, C.1, Autor
Ruzzenente, B.1, Autor
Tain, L.1, Autor
Gronke, S.1, Autor
Baggio, F.1, Autor
Kukat, C.1, Autor
Kremmer, E.1, Autor
Wibom, R.1, Autor
Polosa, P. L.1, Autor
Habermann, B.1, Autor
Partridge, L.1, Autor
Park, C. B.1, Autor
Larsson, N. G.1, Autor
Affiliations:
1Max Planck Society, ou_persistent13              

Inhalt

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Schlagwörter: Animals DNA, Mitochondrial/genetics *Drosophila Proteins/genetics Drosophila melanogaster/*genetics Gene Expression Regulation Invertebrates/genetics/metabolism Mice *Mitochondria/genetics/metabolism *Mitochondrial Proteins/genetics Oxidative Phosphorylation *Ribosomes/genetics/metabolism Transcription, Genetic
 Zusammenfassung: Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial transcription termination factor 3 (MTERF3) is a key regulator that represses mtDNA transcription in the mouse, but its molecular mode of action has remained elusive. Based on the hypothesis that key regulatory mechanisms for mtDNA expression are conserved in metazoans, we analyzed Mterf3 knockout and knockdown flies. We demonstrate here that decreased expression of MTERF3 not only leads to activation of mtDNA transcription, but also impairs assembly of the large mitochondrial ribosomal subunit. This novel function of MTERF3 in mitochondrial ribosomal biogenesis is conserved in the mouse, thus we identify a novel and unexpected role for MTERF3 in coordinating the crosstalk between transcription and translation for the regulation of mammalian mtDNA gene expression.

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 Datum: 2013
 Publikationsstatus: Im Druck publiziert
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: 23300484
DOI: 10.1371/journal.pgen.1003178
ISSN: 1553-7404 (Electronic) 1553-7390 (Linking)
 Art des Abschluß: -

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Titel: PLoS Genet
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 9 (1) Artikelnummer: - Start- / Endseite: e1003178 Identifikator: -