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  Dorsal premotor cortex exerts state-dependent causal influences on activity in contralateral primary motor and dorsal premotor cortex

Bestmann, S., Swayne, O., Blankenburg, F., Ruff, C. C., Haggard, P., Weiskopf, N., et al. (2008). Dorsal premotor cortex exerts state-dependent causal influences on activity in contralateral primary motor and dorsal premotor cortex. Cerebral Cortex, 18(6), 1281-1291. doi:10.1093/cercor/bhm159.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5E47-C Version Permalink: http://hdl.handle.net/21.11116/0000-0002-4D55-9
Genre: Journal Article

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 Creators:
Bestmann, Sven1, 2, 3, Author
Swayne, Orlando2, Author
Blankenburg, Felix1, Author
Ruff, Christian C.1, 3, Author
Haggard, Patrick3, Author
Weiskopf, Nikolaus1, Author              
Josephs, Oliver1, Author
Driver, Jon1, 3, Author
Rothwell, John C.2, Author
Ward, Nick S.1, 4, Author
Affiliations:
1Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
2Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
3Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
4Department of Brain Repair & Rehabilitation, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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Free keywords: Concurrent TMS-fMRI; Effective connectivity; Grip force; Motor preparation; Transcallosal inhibition
 Abstract: During voluntary action, dorsal premotor cortex (PMd) may exert influences on motor regions in both hemispheres, but such interregional interactions are not well understood. We used transcranial magnetic stimulation (TMS) concurrently with event-related functional magnetic resonance imaging to study such interactions directly. We tested whether causal influences from left PMd upon contralateral (right) motor areas depend on the current state of the motor system, involving regions engaged in a current task. We applied short bursts (360 ms) of high- or low-intensity TMS to left PMd during single isometric left-hand grips or during rest. TMS to left PMd affected activity in contralateral right PMd and primary motor cortex (M1) in a state-dependent manner. During active left-hand grip, high (vs. low)-intensity TMS led to activity increases in contralateral right PMd and M1, whereas activity decreases there due to TMS were observed during no-grip rest. Analyses of condition-dependent functional coupling confirmed topographically specific stronger coupling between left PMd and right PMd (and right M1), when high-intensity TMS was applied to left PMd during left-hand grip. We conclude that left PMd can exert state-dependent interhemispheric influences on contralateral cortical motor areas relevant for a current motor task.

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Language(s): eng - English
 Dates: 2007-10-262008-06-01
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1093/cercor/bhm159
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Title: Cerebral Cortex
Source Genre: Journal
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Pages: - Volume / Issue: 18 (6) Sequence Number: - Start / End Page: 1281 - 1291 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440