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  Interlocked DNA nanostructures controlled by a reversible logic circuit

Li, T., Lohmann, F., & Famulok, M. (2014). Interlocked DNA nanostructures controlled by a reversible logic circuit. Nature communications, 5, 4940. doi:10.1038/ncomms5940.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-6136-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-42B9-3
Genre: Journal Article

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Li-2014-Interlocked DNA nanostructures control.pdf (Publisher version), 1009KB
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Li, T., Author
Lohmann, F., Author
Famulok, M.1, Author              
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1Max Planck Fellow Chemical Biology, Center of Advanced European Studies and Research (caesar), Max Planck Society, ou_2173681              

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 Abstract: DNA nanostructures constitute attractive devices for logic computing and nanomechanics. An emerging interest is to integrate these two fields and devise intelligent DNA nanorobots. Here we report a reversible logic circuit built on the programmable assembly of a double-stranded (ds) DNA [3]pseudocatenane that serves as a rigid scaffold to position two separate branched-out head-motifs, a bimolecular i-motif and a G-quadruplex. The G-quadruplex only forms when preceded by the assembly of the i-motif. The formation of the latter, in turn, requires acidic pH and unhindered mobility of the head-motif containing dsDNA nanorings with respect to the central ring to which they are interlocked, triggered by release oligodeoxynucleotides. We employ these features to convert the structural changes into Boolean operations with fluorescence labelling. The nanostructure behaves as a reversible logic circuit consisting of tandem YES and AND gates. Such reversible logic circuits integrated into functional nanodevices may guide future intelligent DNA nanorobots to manipulate cascade reactions in biological systems.

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 Dates: 2014
 Publication Status: Published in print
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 Identifiers: Other: 25229207
DOI: 10.1038/ncomms5940
ISSN: 2041-1723 (Electronic)
ISSN: 2041-1723 (Linking)
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Title: Nature communications
  Alternative Title : Nat. Commun.
Source Genre: Journal
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Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: 4940 Identifier: -