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  Regulation of anterior insular cortex activity using real-time fMRI

Caria, A., Veit, R., Sitaram, R., Lotze, M., Weiskopf, N., Grodd, W., et al. (2007). Regulation of anterior insular cortex activity using real-time fMRI. NeuroImage, 35(3), 1238-1246. doi:10.1016/j.neuroimage.2007.01.018.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5F7F-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-CD28-E
Genre: Journal Article

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 Creators:
Caria, Andrea1, 2, Author
Veit, Ralf3, Author
Sitaram, Ranganatha1, Author
Lotze, Martin1, Author
Weiskopf, Nikolaus4, Author              
Grodd, Wolfgang5, Author
Birbaumer, Niels1, 6, Author
Affiliations:
1Institute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University Tübingen, Germany, ou_persistent22              
2Department of Cognitive Science and Education, University of Trento, Italy, ou_persistent22              
3Department of High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
5Section of Experimental MR of the CNS, Department of Radiology, Eberhard Karls University Tübingen, Germany, ou_persistent22              
6Human Cortical Physiology Section, National Institutes of Health, Bethesda, MD, USA, ou_persistent22              

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Free keywords: Self-regulation; Physiological regulation; Real-time fMRI; Brain–computer interface; Neurofeedback; Blood oxygen level-dependent; Insula
 Abstract: Recent advances in functional magnetic resonance imaging (fMRI) data acquisition and processing techniques have made real-time fMRI (rtfMRI) of localized brain areas feasible, reliable and less susceptible to artefacts. Previous studies have shown that healthy subjects learn to control local brain activity with operant training by using rtfMRI-based neurofeedback. In the present study, we investigated whether healthy subjects could voluntarily gain control over right anterior insular activity. Subjects were provided with continuously updated information of the target ROI's level of activation by visual feedback. All participants were able to successfully regulate BOLD-magnitude in the right anterior insular cortex within three sessions of 4 min each. Training resulted in a significantly increased activation cluster in the anterior portion of the right insula across sessions. An increased activity was also found in the left anterior insula but the percent signal change was lower than in the target ROI. Two different control conditions intended to assess the effects of non-specific feedback and mental imagery demonstrated that the training effect was not due to unspecific activations or non feedback-related cognitive strategies. Both control groups showed no enhanced activation across the sessions, which confirmed our main hypothesis that rtfMRI feedback is area-specific. The increased activity in the right anterior insula during training demonstrates that the effects observed are anatomically specific and self-regulation of right anterior insula only is achievable. This is the first group study investigating the volitional control of emotionally relevant brain region by using rtfMRI training and confirms that self-regulation of local brain activity with rtfMRI is possible.

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Language(s): eng - English
 Dates: 2007-01-312007-04-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2007.01.018
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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 35 (3) Sequence Number: - Start / End Page: 1238 - 1246 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166