English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Regulation of emotional responses elicited by threat-related stimuli

Eippert, F., Veit, R., Weiskopf, N., Erb, M., Birbaumer, N., & Anders, S. (2007). Regulation of emotional responses elicited by threat-related stimuli. Human Brain Mapping, 28(5), 409-423. doi:10.1002/hbm.20291.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-6329-D Version Permalink: http://hdl.handle.net/21.11116/0000-0001-6D94-E
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Eippert, Falk1, 2, Author              
Veit, Ralf1, Author
Weiskopf, Nikolaus1, 3, 4, Author              
Erb, Michael3, Author
Birbaumer, Niels1, 5, Author
Anders, Silke1, 3, Author
Affiliations:
1Institute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University Tübingen, Germany, ou_persistent22              
2Graduate School of Neural and Behavioral Sciences, Eberhard Karls University Tübingen, Germany, ou_persistent22              
3Section of Experimental MR of the CNS, Department of Radiology, Eberhard Karls University Tübingen, Germany, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
5Human Cortical Physiology Section, National Institutes of Health, Bethesda, MD, USA, ou_persistent22              

Content

show
hide
Free keywords: Emotion; Cognitive control; Amygdala; Prefrontal cortex; fMRI
 Abstract: The capacity to voluntarily regulate emotions is critical for mental health, especially when coping with aversive events. Several neuroimaging studies of emotion regulation found the amygdala to be a target for downregulation and prefrontal regions to be associated with downregulation. To characterize the role of prefrontal regions in bidirectional emotion regulation and to investigate regulatory influences on amygdala activity and peripheral physiological measures, a functional magnetic resonance imaging (fMRI) study with simultaneous recording of self-report, startle eyeblink, and skin conductance responses was carried out. Subjects viewed threat-related pictures and were asked to up- and downregulate their emotional responses using reappraisal strategies. While startle eyeblink responses (in successful regulators) and skin conductance responses were amplified during upregulation, but showed no consistent effect during downregulation, amygdala activity was increased and decreased according to the regulation instructions. Trial-by-trial ratings of regulation success correlated positively with activity in amygdala during upregulation and orbitofrontal cortex during downregulation. Downregulation was characterized by left-hemispheric activation peaks in anterior cingulate cortex, dorsolateral prefrontal cortex, and orbitofrontal cortex and upregulation was characterized by a pattern of prefrontal activation not restricted to the left hemisphere. Further analyses showed significant overlap of prefrontal activation across both regulation conditions, possibly reflecting cognitive processes underlying both up- and downregulation, but also showed distinct activations in each condition. The present study demonstrates that amygdala responses to threat-related stimuli can be controlled through the use of cognitive strategies depending on recruitment of prefrontal areas, thereby changing the subject's affective state.

Details

show
hide
Language(s): eng - English
 Dates: 2006-11-282007-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/hbm.20291
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 28 (5) Sequence Number: - Start / End Page: 409 - 423 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686