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  Ectodysplasin signalling genes and phenotypic evolution in sculpins (Cottus)

Cheng, J., Sedlazek, F., Altmüller, J., & Nolte, A. W. (2015). Ectodysplasin signalling genes and phenotypic evolution in sculpins (Cottus). Proceedings of the Royal Society B: Biological Sciences, 282(1815): 20150746. doi:10.1098/rspb.2015.0746.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5AD3-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5AD4-E
Genre: Journal Article

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 Creators:
Cheng, Jie1, Author              
Sedlazek, Fritz, Author
Altmüller, Janine, Author
Nolte, Arne W.1, Author              
Affiliations:
1Research Group Evolutionary Genetics of Fishes, Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445645              

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Free keywords: scales; body shape; lateral line; hybrid intermediacy; convergent evolution
 Abstract: Despite their deeply conserved function among vertebrates, ectodysplasin (Eda) signalling genes are involved in microevolutionary change in humans and sticklebacks. If such a dual role is common, Eda signalling genes constitute hotspots for morphological evolution. Variation in sculpin (Cottus) skin prickling and body shape resembles patterns caused by variation in Eda signalling in sticklebacks. We mapped Eda signalling genes and performed quantitative trait locus mapping in crosses between Cottus rhenanus and Cottus perifretum. A genomic region containing the Eda receptor (Edar) was strongly associated with prickling and contributed to shape. The expression of Edar in developing prickles and skeletal elements in Cottus was confirmed by in situ hybridization. Coding sequence changes between Edar alleles in C. rhenanus and C. perifretum exceeded sequence differentiation in other vertebrates. However, it is likely that additional genetic elements besides coding changes affect the phenotypic variation. Although the phenotype in a natural hybrid lineage between C. rhenanus and C. perifretum resembles C. perifretum, the respective coding Edar alleles are not fully fixed (88.6%). Hence, our results support an involvement of Eda signalling in microevolutionary changes, but imply that the Edar gene is affected by multiple evolutionary processes that vary among freshwater sculpins.

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Language(s): eng - English
 Dates: 2015-04-102015-08-132015-09-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1098/rspb.2015.0746
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Title: Proceedings of the Royal Society B: Biological Sciences
  Abbreviation : Proc. R. Soc. B
Source Genre: Journal
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Publ. Info: London : Royal Society
Pages: 9 S. Volume / Issue: 282 (1815) Sequence Number: 20150746 Start / End Page: - Identifier: ISSN: 0962-8452
CoNE: https://pure.mpg.de/cone/journals/resource/110975500577295_2