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  Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over pain

Wiech, K., Kalisch, R., Weiskopf, N., Pleger, B., Stephan, K. E., & Dolan, R. J. (2006). Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over pain. The Journal of Neuroscience, 26(44), 11501-11509. doi:10.1523/JNEUROSCI.2568-06.2006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-65C1-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-CD2E-2
Genre: Journal Article

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 Creators:
Wiech, Katja1, Author
Kalisch, Raffael1, Author
Weiskopf, Nikolaus1, Author              
Pleger, Burkhard1, Author              
Stephan, Klaas Enno1, Author
Dolan , Raymond J.1, Author
Affiliations:
1Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              

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Free keywords: Pain; fMRI; Prefrontal cortex; Cognitive; Emotion; Analgesia
 Abstract: Perceived control attenuates pain and pain-directed anxiety, possibly because it changes the emotional appraisal of pain. We examined whether brain areas associated with voluntary reappraisal of emotional experiences also mediate the analgesic effect of perceived control over pain. Using functional magnetic resonance imaging, we compared self-controlled noxious stimuli with physically identical stimuli that were externally controlled. Self-controlled stimulation was accompanied by less pain and anxiety and higher activation in dorsal anterior cingulate (dACC), right dorsolateral, and bilateral anterolateral prefrontal (alPFC) cortices. Activation in dACC and right alPFC was negatively correlated with pain intensity ratings. For externally controlled pain, activation in right alPFC was inversely correlated with the participants' general belief to have control over their lives. Our results are consistent with a reappraisal view of control and suggest that the analgesic effect of perceived control relies on activation of right alPFC. Failure to activate right alPFC may explain the maladaptive effects of strong general control beliefs during uncontrollable pain.

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Language(s): eng - English
 Dates: 2006-11-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1523/JNEUROSCI.2568-06.2006
 Degree: -

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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Pages: - Volume / Issue: 26 (44) Sequence Number: - Start / End Page: 11501 - 11509 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1