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  Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network

Kalisch, R., Korenfeld, E., Stephan, K. E., Weiskopf, N., Seymour, B., & Dolan, R. J. (2006). Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. The Journal of Neuroscience, 26(37), 9503-9511. doi:10.1523/JNEUROSCI.2021-06.2006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-65C8-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-CD2F-F
Genre: Journal Article

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 Creators:
Kalisch, Raffael1, Author
Korenfeld, Elian1, Author
Stephan, Klaas Enno1, Author
Weiskopf, Nikolaus1, Author              
Seymour, Ben1, Author
Dolan, Raymond J.1, Author
Affiliations:
1Functional Imaging Lab, Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              

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Free keywords: Fear conditioning; Extinction; Context; Hippocampus; Ventromedial prefrontal cortex; Extinction memory
 Abstract: In fear extinction, an animal learns that a conditioned stimulus (CS) no longer predicts a noxious stimulus [unconditioned stimulus (UCS)] to which it had previously been associated, leading to inhibition of the conditioned response (CR). Extinction creates a new CS-noUCS memory trace, competing with the initial fear (CS-UCS) memory. Recall of extinction memory and, hence, CR inhibition at later CS encounters is facilitated by contextual stimuli present during extinction training. In line with theoretical predictions derived from animal studies, we show that, after extinction, a CS-evoked engagement of human ventromedial prefrontal cortex (VMPFC) and hippocampus is context dependent, being expressed in an extinction, but not a conditioning, context. Likewise, a positive correlation between VMPFC and hippocampal activity is extinction context dependent. Thus, a VMPFC-hippocampal network provides for context-dependent recall of human extinction memory, consistent with a view that hippocampus confers context dependence on VMPFC.

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Language(s): eng - English
 Dates: 2006-09-13
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1523/JNEUROSCI.2021-06.2006
 Degree: -

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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Pages: - Volume / Issue: 26 (37) Sequence Number: - Start / End Page: 9503 - 9511 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1