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  Mismatch responses to randomized gradient switching noise as reflected by fMRI and whole-head magnetoencephalography

Mathiak, K., Rapp, A., Kircher, T. T. J., Grodd, W., Hertrich, I., Weiskopf, N., et al. (2002). Mismatch responses to randomized gradient switching noise as reflected by fMRI and whole-head magnetoencephalography. Human Brain Mapping, 16(3), 190-195. doi:10.1002/hbm.10041.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-66C3-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-CD39-8
Genre: Journal Article

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 Creators:
Mathiak, Klaus1, 2, 3, Author
Rapp, Alexander4, Author
Kircher, Tilo T. J.4, Author
Grodd, Wolfgang1, Author
Hertrich, Ingo2, Author
Weiskopf, Nikolaus1, 5, Author              
Lutzenberger, Werner3, Author
Ackermann, Herrmann2, Author
Affiliations:
1Department of Radiology, Eberhard Karls University Tübingen, Germany, ou_persistent22              
2Department of Neurology, Eberhard Karls University Tübingen, Germany, ou_persistent22              
3MEG Center, Eberhard Karls University Tübingen, Germany, ou_persistent22              
4Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany, ou_persistent22              
5Institute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University Tübingen, Germany, ou_persistent22              

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Free keywords: Functional magnetic resonance imaging; Auditory stimulation; Gradient switching; Mismatch negativity
 Abstract: The central auditory system of the human brain uses a variety of mechanisms to analyze auditory scenes, among others, preattentive detection of sudden changes in the sound environment. Electroencephalography (EEG) and magnetoencephalography (MEG) provide a measure to monitor neuronal cortical currents. The mismatch negativity (MMN) or field (MMNm) reflect preattentive activation in response to deviants within a sequence of homogenous auditory stimuli. Functional magnetic resonance imaging (fMRI) allows for a higher spatial resolution as compared to the extracranial electrophysiological techniques. The image encoding gradients of echo planar imaging (EPI) sequences, however, elicit an interfering background noise. To circumvent this shortcoming, the present study applied multi-echo EPI mimicking an auditory oddball design. The gradient trains (SOA = 800 msec, 94.5 dB SPL, stimulus duration = 152 msec) comprised amplitude (-9 dB) and duration (76 msec) deviants in a randomized sequence. Moreover, the scanner noise was recorded and applied in a whole-head MEG device to validate the properties of this specific material. Robust fMRI activation patterns emerged in response to the deviant gradient switching. Changes in amplitude activated the entire auditory cortex, whereas the duration deviants elicited right-lateralized signal increase in secondary areas. The recorded scanner noise evoked reliably right-lateralized mismatch MEG responses. Source localization was in accordance with activation of secondary auditory cortex. The presented paradigm provides a robust and feasible tool to study the functional anatomy of early cognitive auditory processing in clinical populations such as schizophrenia.

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Language(s): eng - English
 Dates: 2002-05-232002-07-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/hbm.10041
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Pages: - Volume / Issue: 16 (3) Sequence Number: - Start / End Page: 190 - 195 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686