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  Reversible light switch for macrocycle mobility in a DNA rotaxane

Lohmann, F., Ackermann, D., & Famulok, M. (2012). Reversible light switch for macrocycle mobility in a DNA rotaxane. Journal of the American Chemical Society, 134(29), 11884-7. doi:10.1021/ja3042096.

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http://www.ncbi.nlm.nih.gov/pubmed/22780815 (beliebiger Volltext)
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 Urheber:
Lohmann, F., Autor
Ackermann, D., Autor
Famulok, M.1, Autor
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1External Organizations, ou_persistent22              

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Schlagwörter: Base Sequence DNA/*chemistry Light Macrocyclic Compounds/*chemistry Molecular Sequence Data Nanostructures/chemistry Rotaxanes/*chemistry
 Zusammenfassung: A recent trend in DNA nanotechnology consists of the assembly of architectures with dynamic properties that can be regulated by employing external stimuli. Reversible processes are important for implementing molecular motion into DNA architectures as they allow for the regeneration of the original state. Here we describe two different approaches for the reversible switching of a double-stranded DNA rotaxane architecture from a stationary pseudorotaxane mode into a state with movable components. Both states only marginally differ in their respective topologies but their mechanical properties are fundamentally different. In the two approaches, the switching operation is based on strand-displacement reactions. One of them employs toehold-extended oligodeoxynucleotides whereas in the other one the switching is achieved by light-irradiation. In both cases, multiple back and forth switching between the stationary and the mobile states was achieved in nearly quantitative fashion. The ability to reversibly operate mechanical motion in an interlocked DNA nanostructure opens exciting new avenues in DNA nanotechnology.

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 Datum: 2012
 Publikationsstatus: Erschienen
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 Identifikatoren: Anderer: 22780815
DOI: 10.1021/ja3042096
ISSN: 1520-5126 (Electronic)
ISSN: 0002-7863 (Linking)
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Titel: Journal of the American Chemical Society
  Alternativer Titel : J. Am. Chem. Soc.
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 134 (29) Artikelnummer: - Start- / Endseite: 11884 - 7 Identifikator: -