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  Aptamers for allosteric regulation

Vinkenborg, J. L., Karnowski, N., & Famulok, M. (2011). Aptamers for allosteric regulation. Nature chemical biology, 7(8), 519-27. doi:10.1038/nchembio.609.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-6420-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-6421-6
Genre: Journal Article

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Vinkenborg-2011-Aptamers for alloste.pdf (Any fulltext), 929KB
 
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Vinkenborg, J. L., Author
Karnowski, N., Author
Famulok, M.1, Author
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Free keywords: Allosteric Regulation/physiology Aptamers, Nucleotide/*metabolism *Computers, Molecular Gene Expression Regulation/*physiology *Protein Engineering
 Abstract: Aptamers are useful for allosteric regulation because they are nucleic acid-based structures in which ligand binding induces conformational changes that may alter the function of a connected oligonucleotide at a distant site. Through this approach, a specific input is efficiently converted into an altered output. This property makes these biomolecules ideally suited to function as sensors or switches in biochemical assays or inside living cells. The ability to select oligonucleotide-based recognition elements in vitro in combination with the availability of nucleic acids with enzymatic activity has led to the development of a wide range of engineered allosteric aptasensors and aptazymes. Here, we discuss recent progress in the screening, design and diversity of these conformational switching oligonucleotides. We cover their application in vitro and for regulating gene expression in both prokaryotes and eukaryotes.

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 Dates: 2011
 Publication Status: Published in print
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 Identifiers: Other: 21769099
DOI: 10.1038/nchembio.609
ISSN: 1552-4469 (Electronic)
ISSN: 1552-4450 (Linking)
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Title: Nature chemical biology
  Alternative Title : Nat. Chem. Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 7 (8) Sequence Number: - Start / End Page: 519 - 27 Identifier: -