English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., et al. (2008). Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nature Immunology, 9(8), 847-856.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-6482-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-6483-8
Genre: Journal Article

Files

show Files
hide Files
:
Hornung_Silica.pdf (Any fulltext), 688KB
 
File Permalink:
-
Name:
Hornung_Silica.pdf
Description:
-
OA-Status:
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
http://www.nature.com/ni/journal/v9/n8/pdf/ni.1631.pdf (Any fulltext)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Hornung, V., Author
Bauernfeind, F., Author
Halle, A.1, Author
Samstad, E. O., Author
Kono, H., Author
Rock, K. L., Author
Fitzgerald, K. A., Author
Latz, E., Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: ACTIVATION Cells MECHANISM RECEPTOR
 Abstract: Inhalation of silica crystals causes inflammation in the alveolar space. Prolonged exposure to silica can lead to the development of silicosis, an irreversible, fibrotic pulmonary disease. The mechanisms by which silica and other crystals activate immune cells are not well understood. Here we demonstrate that silica and aluminum salt crystals activated inflammasomes formed by the cytoplasmic receptor NALP3. NALP3 activation required phagocytosis of crystals, and this uptake subsequently led to lysosomal damage and rupture. 'Sterile' lysosomal damage (without crystals) also induced NALP3 activation, and inhibition of either phagosomal acidification or cathepsin B activity impaired NALP3 activation. Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal

Details

show
hide
Language(s):
 Dates: 2008
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000257780700007
ISSN: 1529-2908
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Immunology
  Alternative Title : Nat. Immunol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 9 (8) Sequence Number: - Start / End Page: 847 - 856 Identifier: -