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  CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans

Aklillu, E., Odenthal-Hesse, L., Bowdrey, J., Habtewold, A., Ngaimisi, E., Yimer, G., et al. (2013). CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans. BMC Infectious Diseases, 13: 536. doi:10.1186/1471-2334-13-536.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-6198-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C910-7
Genre: Journal Article

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 Creators:
Aklillu, Eleni, Author
Odenthal-Hesse, Linda1, Author              
Bowdrey, Jennifer, Author
Habtewold, Abiy, Author
Ngaimisi, Eliford, Author
Yimer, Getnet, Author
Amogne, Wondwossen, Author
Mugusi, Sabina, Author
Minzi, Omary, Author
Makonnen, Eyasu, Author
Janabi, Mohammed, Author
Mugusi, Ferdinand, Author
Aderaye, Getachew, Author
Hardwick, Robert, Author
Fu, Beiyuan, Author
Viskaduraki, Maria, Author
Yang, Fengtang, Author
Hollox, Edward J, Author
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1External Organizations, ou_persistent22              

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 Abstract: Background The role of copy number variation of the CCL3L1 gene, encoding MIP1α, in contributing to the host variation in susceptibility and response to HIV infection is controversial. Here we analyse a sub-Saharan African cohort from Tanzania and Ethiopia, two countries with a high prevalence of HIV-1 and a high co-morbidity of HIV with tuberculosis. Methods We use a form of quantitative PCR called the paralogue ratio test to determine CCL3L1 gene copy number in 1134 individuals and validate our copy number typing using array comparative genomic hybridisation and fiber-FISH. Results We find no significant association of CCL3L1 gene copy number with HIV load in antiretroviral-naïve patients prior to initiation of combination highly active anti-retroviral therapy. However, we find a significant association of low CCL3L1 gene copy number with improved immune reconstitution following initiation of highly active anti-retroviral therapy (p = 0.012), replicating a previous study. Conclusions Our work supports a role for CCL3L1 copy number in immune constitution following antiretroviral therapy in HIV, and suggests that the MIP1α -CCR5 axis might be targeted to aid immune reconstitution.

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Language(s): eng - English
 Dates: 2013-05-292013-10-282013-11-12
 Publication Status: Published online
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 Identifiers: DOI: 10.1186/1471-2334-13-536
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Title: BMC Infectious Diseases
  Other : BMC Infect Dis
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: - Volume / Issue: 13 Sequence Number: 536 Start / End Page: - Identifier: ISSN: 1471-2334
CoNE: https://pure.mpg.de/cone/journals/resource/111000136906036