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  A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

Hinds, D. A., McMahon, G., Kiefer, A. K., Do, C. B., Eriksson, N., Evans, D. M., et al. (2013). A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nat Genet, 45(8), 907-911. doi:10.1038/ng.2686.

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Hinds_etal_genome-wide_2013.pdf (Publisher version), 580KB
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Hinds, David A., Author
McMahon, George, Author
Kiefer, Amy K., Author
Do, Chuong B., Author
Eriksson, Nicholas, Author
Evans, David M., Author
St Pourcain, Beate1, Author           
Ring, Susan M., Author
Mountain, Joanna L., Author
Francke, Uta, Author
Davey-Smith, George, Author
Timpson, Nicholas J., Author
Tung, Joyce Y., Author
Affiliations:
1University of Bristol, Bristol, UK, ou_persistent22              

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Free keywords: Adult, Aged, Allergens, Animals, Cats, Cohort Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Hypersensitivity, Male, Middle Aged, Polymorphism, Single Nucleotide, Pyroglyphidae, Self Report, Young Adult
 Abstract: Allergic disease is very common and carries substantial public-health burdens. We conducted a meta-analysis of genome-wide associations with self-reported cat, dust-mite and pollen allergies in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with association P<5×10(-8), including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P=5.3×10(-21)); 6p21.33 near HLA-C and MICA (rs9266772, P=3.2×10(-12)); 5p13.1 near PTGER4 (rs7720838, P=8.2×10(-11)); 2q33.1 in PLCL1 (rs10497813, P=6.1×10(-10)), 3q28 in LPP (rs9860547, P=1.2×10(-9)); 20q13.2 in NFATC2 (rs6021270, P=6.9×10(-9)), 4q27 in ADAD1 (rs17388568, P=3.9×10(-8)); and 14q21.1 near FOXA1 and TTC6 (rs1998359, P=4.8×10(-8)). We identified one locus with substantial evidence of differences in effects across allergies at 6p21.32 in the class II human leukocyte antigen (HLA) region (rs17533090, P=1.7×10(-12)), which was strongly associated with cat allergy. Our study sheds new light on the shared etiology of immune and autoimmune disease.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/ng.2686
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Title: Nat Genet
Source Genre: Journal
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Pages: - Volume / Issue: 45 (8) Sequence Number: - Start / End Page: 907 - 911 Identifier: ISSN: 1546-1718