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  Immunity comes first: the effect of parasite genotypes on adaptive immunity and immunization in three-spined sticklebacks

Haase, D., Rieger, J. K., Witten, A., Stoll, M., Bornberg-Bauer, E., Kalbe, M., et al. (2016). Immunity comes first: the effect of parasite genotypes on adaptive immunity and immunization in three-spined sticklebacks. Developmental and Comparative Immunology, 54(1): 2459, pp. 137-144. doi:10.1016/j.dci.2015.09.008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-7ADD-D Version Permalink: http://hdl.handle.net/21.11116/0000-0000-2E80-C
Genre: Journal Article

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Haase_et_al_2015.pdf (Publisher version), 993KB
 
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 Creators:
Haase, David, Author
Rieger, Jennifer K., Author
Witten, Anika, Author
Stoll, Monika, Author
Bornberg-Bauer, Erich, Author
Kalbe, Martin1, Author              
Reusch, Thorsten B. H.2, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2External, ou_persistent22              

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Free keywords: Adaptive immunity; Diplostomum pseudospathaceum; Gasterosteus aculeatus; Parasite; RNA-seq; Transcriptomics
 Abstract: Abstract Adaptive immunity in vertebrates can confer increased resistance against invading pathogens upon re-infection. But how specific parasite genotypes affect the temporal transition from innate to adaptive immunity under continual exposure to parasites is poorly understood. Here, we investigated the effects of homologous and heterologous exposures of genetically distinct parasite lineages of the eye fluke Diplostomum pseudospathaceum on gene expression patterns of adaptive immunity in sticklebacks (Gasterosteus aculeatus). Observable differences in gene expression were largely attributable to final exposures while there was no transcription pattern characteristic for a general response to repeated infections with D. pseudospathaceum. None of the final exposure treatments was able to erase the distinct expression patterns resulting from a heterologous pre-exposed fish. Interestingly, heterologous final exposures showed similarities between different treatment groups subjected to homologous pre-exposure. The observed pattern was supported by parasite infection rates and suggests that host immunization was optimized towards an adaptive immune response that favored effectiveness against parasite diversity over specificity.

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Language(s): eng - English
 Dates: 2015-09-162015-03-312015-09-172015-09-212016-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.dci.2015.09.008
BibTex Citekey: Haase2016137
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Project name : Priority Programme on Host-Parasite Coevolution
Grant ID : RE 1108/13-2
Funding program : (SPP 1399)
Funding organization : Deutsche Forschungsgemeinschaft

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Title: Developmental and Comparative Immunology
Source Genre: Journal
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Publ. Info: New York : Pergamon
Pages: - Volume / Issue: 54 (1) Sequence Number: 2459 Start / End Page: 137 - 144 Identifier: ISSN: 0145-305X
CoNE: /journals/resource/954925473401