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  Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma

Meierhofer, D., Mayr, J. A., Foetschl, U., Berger, A., Fink, K., Schmeller, N., et al. (2004). Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma. Carcinogenesis, 25(6), 1005-1010. doi:10.1093/carcin/bgh104.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-8F5A-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-8F5B-E
Genre: Journal Article

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Meierhofer.pdf (Publisher version), 249KB
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© 2004 Oxford University Press
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 Creators:
Meierhofer, David1, 2, Author              
Mayr, Johannes A.2, Author
Foetschl, Ulrike2, Author
Berger, Alexandra2, Author
Fink, Klaus, Author
Schmeller, Nikolaus, Author
Hacker, Gerhard W., Author
Hauser-Kronberger, Cornelia, Author
Kofler, Barbara2, Author
Sperl, Wolfgang2, Author
Affiliations:
1Mass Spectrometry (Head: David Meierhofer), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479669              
2Department of Pediatrics, Paracelsus Private Medical University Salzburg, A-5020 Salzburg, Austria , ou_persistent22              

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Free keywords: COX, cytochrome c oxidase, m/r ratio, relative ratio of mitochondrial DNA to 18S rDNA, OXPHOS, oxidative phosphorylation
 Abstract: To elucidate the relationship between tumorgenesis and the mitochondrial energy metabolism in renal neoplasms, we studied three individual enzyme activities of the oxidative phosphorylation, two components of the Krebs cycle and the mitochondrial DNA content of renal carcinomas including 29 conventional, five papillary, two unclassified carcinomas with sarcomatoid features and one collecting duct carcinoma. A significant reduction of all mitochondrial enzyme activities including complex V, as well as of the mitochondrial DNA content was detected in 34 of 37 renal carcinoma tissues as compared with control kidney. Mitochondrial enzyme activities and mitochondrial DNA levels were not statistically different between the conventional, papillary and unclassified sarcomatoid type of renal carcinoma and did not correlate with tumour grade, metastasis, ploidy and proliferative activity as determined by Ki-67 staining. Taken together, our data indicate that a co-ordinated down-regulation of all components necessary for mitochondrial energy metabolism occurs in most renal carcinomas as an early event in carcinoma formation, which does not change with progression of the disease.

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Language(s): eng - English
 Dates: 2004-02-042004-06
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1093/carcin/bgh104
 Degree: -

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Title: Carcinogenesis
Source Genre: Journal
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Publ. Info: London [etc. : IRL Press]
Pages: - Volume / Issue: 25 (6) Sequence Number: - Start / End Page: 1005 - 1010 Identifier: ISSN: 0143-3334
CoNE: /journals/resource/954925472375