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  Integrating mitochondrial translation into the cellular context.

Richter-Dennerlein, R., Dennerlein, S., & Rehling, P. (2015). Integrating mitochondrial translation into the cellular context. Nature Reviews Molecular Cell Biology, 16(10), 586-592. doi:10.1038/nrm4051.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-937C-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-5FE1-2
Genre: Journal Article

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2214844.pdf (Publisher version), 755KB
 
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 Creators:
Richter-Dennerlein, R., Author
Dennerlein, S., Author
Rehling, P.1, Author              
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1Max Planck Fellow Peter Rehling, ou_1298545              

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 Abstract: Mitochondrial-encoded subunits of the oxidative phosphorylation system assemble with nuclear-encoded subunits into enzymatic complexes. Recent findings showed that mitochondrial translation is linked to other mitochondrial functions, as well as to cellular processes. The supply of mitochondrial- encoded proteins is coordinated by the coupling of mitochondrial protein synthesis with assembly of respiratory chain complexes. MicroRNAs imported from the cytoplasm into mitochondria were, surprisingly, found to act as regulators of mitochondrial translation. In turn, translation in mitochondria controls cellular proliferation, and mitochondrial ribosomal subunits contribute to the cytoplasmic stress response. Thus, translation in mitochondria is apparently integrated into cellular processes.

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Language(s): eng - English
 Dates: 2015-09-162015-10
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/nrm4051
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Title: Nature Reviews Molecular Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 16 (10) Sequence Number: - Start / End Page: 586 - 592 Identifier: -