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  Dissociating parieto-frontal networks for phonological and semantic word decisions: A condition-and-perturb TMS study

Hartwigsen, G., Weigel, A., Schuschan, P., Siebner, H. R., Weise, D., Classen, J., et al. (2016). Dissociating parieto-frontal networks for phonological and semantic word decisions: A condition-and-perturb TMS study. Cerebral Cortex, 26(6), 2590-2601. doi:10.1093/cercor/bhv092.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-AAD4-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-606B-9
Genre: Journal Article

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 Creators:
Hartwigsen, Gesa1, 2, 3, Author              
Weigel, Anni1, Author
Schuschan, Paul1, Author
Siebner, Hartwig R.4, Author
Weise, David5, Author
Classen, Joseph5, Author
Saur, Dorothee1, 2, Author
Affiliations:
1Language & Aphasia Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
3Department of Psychology, Christian Albrecht University Kiel, Germany, ou_persistent22              
4Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              
5Human Cortical Physiology and Motor Control Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Inferior frontal gyrus; Language; Parietal cortex; Transcranial magnetic stimulation; Virtual lesion
 Abstract: Left posterior inferior frontal gyrus (pIFG) and supramarginal gyrus (SMG) are key regions for phonological decisions, whereas angular gyrus (ANG) and anterior IFG (aIFG) are associated with semantics. However, it is less clear whether the functional contribution of one area changes in the presence of a dysfunctional area within the network. Using repetitive transcranial magnetic stimulation (rTMS), we first tested whether perturbing one area would disrupt behavior. Second, we applied a condition-and-perturb approach, combining parietal offline rTMS with frontal online rTMS to investigate how the functional contribution of a frontal region changes in the presence of a dysfunctional parietal region. We found that rTMS over SMG or pIFG delayed phonological decisions, but this was not enhanced by combining supramarginal rTMS with pIFG rTMS. In contrast, semantic decisions were only impaired when angular rTMS was combined with aIFG rTMS. We infer that offline rTMS caused a dysfunction of ANG which increased the functional relevance of aIFG for semantic decisions and sensitized this network to the disruptive effects of aIFG rTMS. The results provide causal evidence that ANG and aIFG contribute to semantics and that the functional significance of one area within this network depends on the functional integrity of the other.

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Language(s): eng - English
 Dates: 2015-05-072016-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhv092
PMID: 25953770
Other: Epub 2015 M
 Degree: -

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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 26 (6) Sequence Number: - Start / End Page: 2590 - 2601 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440