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  Increased facilitatory connectivity from the pre-SMA to the left dorsal premotor cortex during pseudoword repetition

Hartwigsen, G., Saur, D., Price, C. J., Baumgaertner, A., Ulmer, S., & Siebner, H. R. (2013). Increased facilitatory connectivity from the pre-SMA to the left dorsal premotor cortex during pseudoword repetition. Journal of Cognitive Neuroscience, 25(4), 580-594. doi:10.1162/jocn_a_00342.

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 Creators:
Hartwigsen, Gesa1, 2, 3, Author              
Saur, Dorothee3, Author
Price, Cathy J.4, Author
Baumgaertner, Annette1, 2, 5, Author
Ulmer, Stephan6, 7, Author
Siebner, Hartwig R.1, 2, 8, Author
Affiliations:
1Christian Albrecht University Kiel, Germany, ou_persistent22              
2Neuroimage Nord, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
3University of Leipzig, Germany, ou_persistent22              
4University College London, United Kingdom, ou_persistent22              
5Fresenius University of Applied Sciences, Hamburg, Germany, ou_persistent22              
6University Hospital of Schleswig-Holstein, Kiel, Germany, ou_persistent22              
7University Hospital Basel, Switzerland, ou_persistent22              
8Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              

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 Abstract: Previous studies have demonstrated that the repetition of pseudowords engages a network of premotor areas for articulatory planning and articulation. However, it remains unclear how these premotor areas interact and drive one another during speech production. We used fMRI with dynamic causal modeling to investigate effective connectivity between premotor areas during overt repetition of words and pseudowords presented in both the auditory and visual modalities. Regions involved in phonological aspects of language production were identified as those where regional increases in the BOLD signal were common to repetition in both modalities. We thus obtained three seed regions: the bilateral pre-SMA, left dorsal premotor cortex (PMd), and left ventral premotor cortex that were used to test 63 different models of effective connectivity in the premotor network for pseudoword relative to word repetition. The optimal model was identified with Bayesian model selection and reflected a network with driving input to pre-SMA and an increase in facilitatory drive from pre-SMA to PMd during repetition of pseudowords. The task-specific increase in effective connectivity from pre-SMA to left PMd suggests that the pre-SMA plays a supervisory role in the generation and subsequent sequencing of motor plans. Diffusion tensor imaging-based fiber tracking in another group of healthy volunteers showed that the functional connection between both regions is underpinned by a direct cortico-cortical anatomical connection.

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Language(s): eng - English
 Dates: 2013-02-282013-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1162/jocn_a_00342
PMID: 23249347
Other: Epub 2012
 Degree: -

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Title: Journal of Cognitive Neuroscience
Source Genre: Journal
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Publ. Info: Cambridge, MA : MIT Press Journals
Pages: - Volume / Issue: 25 (4) Sequence Number: - Start / End Page: 580 - 594 Identifier: ISSN: 0898-929X
CoNE: https://pure.mpg.de/cone/journals/resource/991042752752726