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  Left dorsal premotor cortex and supramarginal gyrus complement each other during rapid action reprogramming

Hartwigsen, G., Bestmann, S., Ward, N. S., Woerbel, S., Mastroeni, C., Granert, O., et al. (2012). Left dorsal premotor cortex and supramarginal gyrus complement each other during rapid action reprogramming. The Journal of Neuroscience, 32(46), 16162-16171. doi:10.1523/JNEUROSCI.1010-12.2012.

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 Creators:
Hartwigsen, Gesa1, 2, Author           
Bestmann, Sven3, Author
Ward, Nick S.3, 4, Author
Woerbel, Saskia1, Author
Mastroeni, Claudia1, Author
Granert, Oliver1, Author
Siebner, Hartwig R.1, 5, Author
Affiliations:
1Department of Neurology, Christian Albrecht University Kiel, Germany, ou_persistent22              
2Language & Aphasia Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Department of Brain Repair & Rehabilitation, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              

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 Abstract: The ability to discard a prepared action plan in favor of an alternative action is critical when facing sudden environmental changes. We tested whether the functional contribution of left supramarginal gyrus (SMG) during action reprogramming depends on the functional integrity of left dorsal premotor cortex (PMd). Adopting a dual-site repetitive transcranial magnetic stimulation (rTMS) strategy, we first transiently disrupted PMd with “off-line” 1 Hz rTMS and then applied focal “on-line” rTMS to SMG while human subjects performed a spatially precued reaction time (RT) task. Effective on-line rTMS of SMG but not sham rTMS of SMG increased errors when subjects had to reprogram their action in response to an invalid precue regardless of the type of preceding off-line rTMS. This suggests that left SMG primarily contributes to the on-line updating of actions by suppressing invalidly prepared responses. On-line rTMS of SMG additionally increased RTs for correct responses in invalidly precued trials, but only after off-line rTMS of PMd. We infer that off-line rTMS caused an additional dysfunction of PMd, which increased the functional relevance of SMG for rapid activation of the correct response, and sensitized SMG to the disruptive effects of on-line rTMS. These results not only provide causal evidence that left PMd and SMG jointly contribute to action reprogramming, but also that the respective functional weight of these areas can be rapidly redistributed. This mechanism might constitute a generic feature of functional networks that allows for rapid functional compensation in response to focal dysfunctions.

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Language(s): eng - English
 Dates: 2012-08-152012-02-292012-09-132012-11-14
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.1010-12.2012
PMID: 23152600
PMC: PMC3558742
 Degree: -

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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Affiliations:
Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 32 (46) Sequence Number: - Start / End Page: 16162 - 16171 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187