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  Damage to ventral and dorsal language pathways in acute aphasia

Kümmerer, D., Hartwigsen, G., Kellmeyer, P., Glauche, V., Mader, I., Klöppel, S., et al. (2013). Damage to ventral and dorsal language pathways in acute aphasia. Brain, 136(2), 619-629. doi:10.1093/brain/aws354.

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 Creators:
Kümmerer, Dorothee1, 2, Author
Hartwigsen, Gesa3, Author              
Kellmeyer, Philipp1, 2, Author
Glauche, Volkmar1, 2, Author
Mader, Irina2, 4, Author
Klöppel, Stefan1, 2, 5, Author
Suchan, Julia6, Author
Karnath, Hans-Otto6, 7, Author
Weiller, Cornelius1, 2, Author
Saur, Dorothee3, Author
Affiliations:
1Department of Neurology, University Medical Center, Freiburg, Germany, ou_persistent22              
2Freiburg Brain Imaging, University Medical Center, Freiburg, Germany, ou_persistent22              
3Language & Aphasia Laboratory, University of Leipzig, Germany, ou_persistent22              
4Department of Neuroradiology, University Medical Center, Freiburg, Germany, ou_persistent22              
5Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany, ou_persistent22              
6Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Germany, ou_persistent22              
7Department of Psychology, University of South Carolina, Columbia, SC, USA, ou_persistent22              

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Free keywords: Stroke; Voxelwise lesion-behaviour mapping; Extreme capsule; Superior longitudinal fascicle; Arcuate fascicle
 Abstract: Converging evidence from neuroimaging studies and computational modelling suggests an organization of language in a dual dorsal–ventral brain network: a dorsal stream connects temporoparietal with frontal premotor regions through the superior longitudinal and arcuate fasciculus and integrates sensorimotor processing, e.g. in repetition of speech. A ventral stream connects temporal and prefrontal regions via the extreme capsule and mediates meaning, e.g. in auditory comprehension. The aim of our study was to test, in a large sample of 100 aphasic stroke patients, how well acute impairments of repetition and comprehension correlate with lesions of either the dorsal or ventral stream. We combined voxelwise lesion-behaviour mapping with the dorsal and ventral white matter fibre tracts determined by probabilistic fibre tracking in our previous study in healthy subjects. We found that repetition impairments were mainly associated with lesions located in the posterior temporoparietal region with a statistical lesion maximum in the periventricular white matter in projection of the dorsal superior longitudinal and arcuate fasciculus. In contrast, lesions associated with comprehension deficits were found more ventral-anterior in the temporoprefrontal region with a statistical lesion maximum between the insular cortex and the putamen in projection of the ventral extreme capsule. Individual lesion overlap with the dorsal fibre tract showed a significant negative correlation with repetition performance, whereas lesion overlap with the ventral fibre tract revealed a significant negative correlation with comprehension performance. To summarize, our results from patients with acute stroke lesions support the claim that language is organized along two segregated dorsal–ventral streams. Particularly, this is the first lesion study demonstrating that task performance on auditory comprehension measures requires an interaction between temporal and prefrontal brain regions via the ventral extreme capsule pathway.

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Language(s): eng - English
 Dates: 2012-11-192011-11-292012-11-262013-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/brain/aws354
PMID: 23378217
PMC: PMC3572927
Other: Epub 2013
 Degree: -

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Title: Brain
  Other : Brain
Source Genre: Journal
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Publ. Info: London : Macmillan
Pages: - Volume / Issue: 136 (2) Sequence Number: - Start / End Page: 619 - 629 Identifier: ISSN: 0006-8950
CoNE: https://pure.mpg.de/cone/journals/resource/954925385135